Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 2541912, 8 pages
http://dx.doi.org/10.1155/2016/2541912
Research Article

Colchicum autumnale in Patients with Goitre with Euthyroidism or Mild Hyperthyroidism: Indications for a Therapeutic Regulative Effect—Results of an Observational Study

1Integrated Curriculum for Anthroposophic Medicine, Institute for Integrative Medicine, Faculty for Health, Department for Medicine, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany
2Gemeinschaftskrankenhaus Herdecke, Department for Internal Medicine, Gerhard-Kienle-Weg 4, 58313 Herdecke, Germany
3Research Institute Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany
4Department of Internal Medicine, Havelhöhe Hospital, Kladower Damm 221, 14089 Berlin, Germany
5Institute for Integrative Medicine, Faculty for Health, Department for Medicine, University of Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany

Received 19 August 2015; Revised 22 December 2015; Accepted 30 December 2015

Academic Editor: Jonathan L. Wardle

Copyright © 2016 Christian Scheffer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Meisinger, T. Ittermann, H. Wallaschofski et al., “Geographic variations in the frequency of thyroid disorders and thyroid peroxidase antibodies in persons without former thyroid disease within Germany,” European Journal of Endocrinology, vol. 167, no. 3, pp. 363–371, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Hermus and D. Huysmans, “Pathogenesis of nontoxic diffuse and nodular goiter,” in Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text, L. E. Braverman and R. D. Utiger, Eds., pp. 861–865, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 8th edition, 2000. View at Google Scholar
  3. D. Führer, A. Bockisch, and K. W. Schmid, “Euthyroid goiter with and without nodules—diagnosis and treatment,” Deutsches Ärzteblatt International, vol. 109, no. 29-30, pp. 506–516, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Hegedüs, S. J. Bonnema, and F. N. Bennedbæk, “Management of simple nodular goiter: current status and future perspectives,” Endocrine Reviews, vol. 24, no. 1, pp. 102–132, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Heusser, C. Scheffer, M. Neumann, D. Tauschel, and F. Edelhäuser, “Towards non-reductionistic medical anthropology, medical education and practitioner-patient-interaction: the example of Anthroposophic Medicine,” Patient Education and Counseling, vol. 89, no. 3, pp. 455–460, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. G. S. Kienle, H.-U. Albonico, E. Baars, H. J. Hamre, P. Zimmermann, and H. Kiene, “Anthroposophic medicine: an integrative medical system originating in Europe,” Global Advances in Health and Medicine. Improving Healthcare Outcomes Worldwide, vol. 2, no. 6, pp. 20–31, 2013. View at Google Scholar
  7. R. Steiner and I. Wegman, Fundamentals of Therapy [Grundlegendes für eine Erweiterung der Heilkunst 1925], Mercury Press, New York, NY, USA, 1925.
  8. M. Girke and M. Kröz, “Colchicum autumnale in der therapie der latenten und manifesten hyperthyreose,” Der Merkurstab, vol. 4, pp. 244–248, 2001. View at Google Scholar
  9. D. T. Wade, “Ethics, audit, and research: all shades of grey,” British Medical Journal, vol. 330, no. 7489, pp. 468–471, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Klein, P. T. Trzepacz, M. Roberts, and G. S. Levey, “Symptom rating scale for assessing hyperthyroidism,” Archives of Internal Medicine, vol. 148, no. 2, pp. 387–390, 1988. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Brunn, U. Block, G. Ruf, I. Bos, W. Kunze, and P. C. Scriba, “Volumetrie der Schilddrüsenlappen mittels real-time-Sonographie,” Deutsche Medizinische Wochenschrift, vol. 106, no. 41, pp. 1338–1340, 1981. View at Publisher · View at Google Scholar
  12. G. Hildebrandt and C. Gutenbrunner, “Über adaptive normalisierung,” Forsch Komplemetärmed, vol. 3, no. 5, pp. 236–243, 1996. View at Publisher · View at Google Scholar
  13. C. Gutenbrunner and C. Heckmann, Funktionelle Hygiogenese: Grundlage der Adaptiven Normalisierung, VAS Verlag für Akademische Schriften, Bad Homburg vor der Höhe, Germany, 2013.
  14. J. J. Díez, “Hyperthyroidism in patients older than 55 years: an analysis of the etiology and management,” Gerontology, vol. 49, no. 5, pp. 316–323, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. B. J. Schouten, B. E. W. Brownlie, C. M. Frampton, and J. G. Turner, “Subclinical thyrotoxicosis in an outpatient population—predictors of outcome,” Clinical Endocrinology, vol. 74, no. 2, pp. 257–261, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. F. J. da Cunha Stamato, R. M. de Barros Maciel, P. G. Manso et al., “Colchicine in the treatment of the inflammatory phase of graves' ophthalmopathy: a prospective and randomized trial with prednisone,” Arquivos Brasileiros de Oftalmologia, vol. 69, no. 6, pp. 811–816, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Bongers, L. A. Hotze, R. Schmitz, and K. Joseph, “LT4-monopreparation versus LT4-LT3-compound preparation in the treatment of diffuse endemic goitre,” Acta Endocrinologica, vol. 113, no. 2, pp. 242–248, 1986. View at Google Scholar · View at Scopus
  18. H. Perrild, J. M. Hansen, L. Hegedus et al., “Triiodothyronine and thyroxine treatment of diffuse non-toxic goitre evaluated by ultrasonic scanning,” Acta Endocrinologica, vol. 100, no. 3, pp. 382–387, 1982. View at Google Scholar · View at Scopus
  19. N. Knudsen, B. Bols, I. Bülow et al., “Validation of ultrasonography of the thyroid gland for epidemiological purposes,” Thyroid, vol. 9, no. 11, pp. 1069–1074, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. M. F. T. Wesche, M. M. C. Tiel-v Buul, P. Lips, N. J. Smits, and W. M. Wiersinga, “A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 998–1005, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Berghout, W. M. Wiersinga, J. L. Touber, N. J. Smits, and H. A. Drexhage, “Comparison of placebo with L-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre,” The Lancet, vol. 336, no. 8709, pp. 193–197, 1990. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Wollmann, J. Meller, M. Hüfner, and W. Becker, “Effectiveness of goiter treatment with L-thyroxine in patients over 40,” Nuklearmedizin, vol. 37, no. 1, pp. 41–44, 1998. View at Google Scholar · View at Scopus
  23. A. S. Yap and S. W. Manley, “Microtubule integrity is essential for apical polarization and epithelial morphogenesis in the thyroid,” Cell Motility and the Cytoskeleton, vol. 48, no. 3, pp. 201–212, 2001. View at Google Scholar · View at Scopus
  24. A. S. Yap, B. R. Stevenson, K. C. Abel, E. J. Cragoe Jr., and S. W. Manley, “Microtubule integrity is necessary for the epithelial barrier function of cultured thyroid cell monolayers,” Experimental Cell Research, vol. 218, no. 2, pp. 540–550, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Cysarz, C. Heckmann, H. Bettermann, and H.-C. Kümmell, “Effects of an anthroposophical remedy on cardiorespiratory regulation,” Alternative Therapies in Health and Medicine, vol. 8, no. 6, pp. 78–83, 2002. View at Google Scholar · View at Scopus
  26. NCCAM, Observational Studies and Secondary Data Analyses to Assess Outcomes in Complementary and Integrative Health Care, 2012, http://nccam.nih.gov/research/blog/observational-secondary.
  27. V. Fønnebø, S. Grimsgaard, H. Walach et al., “Researching complementary and alternative treatments—the gatekeepers are not at home,” BMC Medical Research Methodology, vol. 7, article 7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Scheffer, M. Kroetz, M. Debus, C. Heckmann, and M. Girke, “Colchicum autumnale in the treatment of patients with subclinical hyperthyroidism: results of a prospective pilot study,” European Journal of Integrative Medicine, vol. 1, no. 4, pp. 199–200, 2009. View at Publisher · View at Google Scholar