Colchicum autumnale in Patients with Goitre with Euthyroidism or Mild Hyperthyroidism: Indications for a Therapeutic Regulative Effect—Results of an Observational Study

Table 4

Hyperthyroid Symptom Scale (HSS), thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) before (t0), three (t3), and six to twelve (t6–12) months of treatment with Colchicum autumnale.

	t0 median (25–75%)	t3 median (25–75%)	t6–12 median (25–75%)	(t3–>t0)	(t6–12–>t0)
HSS
Group 1	4.5 (2.3 to 11.8)	2 (1.3 to 5)	2 (1.3 to 3)	<0.05	<0.01
Group 2	5.5 (2 to 12.5)	5 (1.3 to 8.8)	5.5 (1 to 13.5)	n.s.	n.s.
Groups 1 and 2	5 (2 to 11.8)	3 (1.3 to 7.5)	2 (1 to 9.8)	<0.05	<0.05
TSH (mU/L)
Group 1	0.2 (0.1 to 0.3)	0.2 (0.13 to 0.28)	0.2 (0.2 to 0.38)	n.s.	n.s.
Group 2	1.2 (0.75 to 1.73)	0.85 (0.6 to 1.15)	0.85 (0.53 to 1.38)	<0.01	<0.01
Groups 1 and 2	0.5 (0.2 to 1.2)	0.4 (0.2 to 0.88)	0.45 (0.2 to 0.88)	<0.05	(<0.1)
fT3 (pg/mL)
Group 1	3.85 (3.5 to 4.78)	3.4 (3.2 to 3.85)	3.45 (3.3 to 3.78)	<0.05	<0.01
Group 2	3.4 (3.13 to 3.58)	3.3 (3 to 3.5)	3.3 (3 to 3.5)	n.s.	n.s.
Groups 1 and 2	3.5 (3.3 to 3.98)	3.35 (3.13 to 3.6)	3.4 (3.1 to 3.65)	(<0.1)	<0.05
fT4 (ng/100 mL)
Group 1	1.15 (0.93 to 1.35)	1.1 (0.93 to 1.35)	1.1 (1 to 1.2)	n.s.	n.s.
Group 2	1.1 (1.03 to 1.35)	1.1 (1 to 1.28)	1.1 (0.9 to 1.28)	n.s.	n.s.
Groups 1 and 2	1.1 (1 to 1.35)	1.1 (1 to 1.3)	1.1 (1 to 1.2)	n.s.	n.s.
Thyroid volume (mL)			Volume change (t6–12 − t0) %
Group 1	27.7 (19.5 to 57.2)		+7 (−0.2 to +15.5)		n.s.
Group 2	27 (23.1 to 42.1)		−13.9 (−18.5 to −6.1)		<0.01
Groups 1 and 2	27.1 (21.3 to 43.7)		−3.8 (−14.7 to +8.7)		n.s.