Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

Figure 3

Effect of baicalin on myocardial remodeling in rats subjected to chronic hypoxia. (a, b) The RV/(LV + S) and RV/BW ratios were significantly increased in the hypoxia group, but baicalin attenuated this trend. (/group), indicates compared to the control group, indicates compared to the hypoxia group, and indicates compared to the hypoxia group. (c) HE staining showed that chronic hypoxia increased right ventricular myocardial hypertrophy and cardiac muscle disorder but that baicalin partially attenuated these effects.

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