Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

Figure 5

Effect of baicalin on MMP-9 protein and mRNA expression in pulmonary arterioles. (a, b) Immunohistochemistry and in situ hybridization techniques showed that both MMP-9 protein and mRNA levels were higher in the hypoxia group than in the control group and that baicalin attenuated this trend. (/group) indicates compared to the control group and indicates compared to the hypoxia group. (c) MMP-9 expression in pulmonary arterioles, as visualized by immunohistochemistry. (d) MMP-9 mRNA expression in pulmonary arterioles, as visualized by in situ hybridization.

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