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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 2601830, 9 pages
http://dx.doi.org/10.1155/2016/2601830
Research Article

Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis

1Traditional Chinese Medicine Department, Affiliated Hospital of Taishan Medical University, Shandong 271000, China
2Gastroenterology Department, Chengdu Second People’s Hospital, Sichuan 610017, China
3Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA
4Gastroenterology Department, Liaocheng Second People’s Hospital, Shandong 252600, China
5Pathology Department, Affiliated Hospital of Taishan Medical University, Shandong 271000, China
6Dermatology Department, Tai’an Maternal and Child Health-Care Hospital, Shandong 271000, China
7Gastroenterology Department, Affiliated Hospital of Taishan Medical University, Shandong 271000, China
8Department of Infectious Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Received 25 November 2015; Accepted 10 January 2016

Academic Editor: Yuewen Gong

Copyright © 2016 Xinjie Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. J. Talley, M. T. Abreu, J. P. Achkar, and American College of Gastroenterology IBD Task Force, “An evidence-based systematic review on medical therapies for inflammatory bowel disease,” The American Journal of Gastroenterology, vol. 106, supplement 1, pp. S2–S25, 2011. View at Publisher · View at Google Scholar
  2. Chinese Group of Inflammatory Bowel Disease, “A retrospective analysis of 3100 cases of ulcerative colitis,” Chinese Journal of Digestive, vol. 26, no. 6, pp. 368–372, 2006. View at Google Scholar
  3. X.-L. Jiang and H.-F. Cui, “An analysis of 10218 ulcerative colitis cases in China,” World Journal of Gastroenterology, vol. 8, no. 1, pp. 158–161, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. E. V. Loftus Jr., “Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences,” Gastroenterology, vol. 126, no. 6, pp. 1504–1517, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. D. S. Pardi and C. P. Kelly, “Microscopic colitis,” Gastroenterology, vol. 140, no. 4, pp. 1155–1165, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Sawczenko and B. K. Sandhu, “Presenting features of inflammatory bowel disease in Great Britain and Ireland,” Archives of Disease in Childhood, vol. 88, no. 11, pp. 995–1000, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. R. D. Cohen, D. M. Woseth, R. A. Thisted, and S. B. Hanauer, “A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis,” The American Journal of Gastroenterology, vol. 95, no. 5, pp. 1263–1276, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. T. T. Zhou and Q. Y. Tong, “Research progress in the pathogenesis of ulcerative colitis,” Chinese Journal of Gastroenterology and Hepatology, vol. 21, no. 2, pp. 1163–1165, 2012. View at Google Scholar
  9. L. B. Zhang, W. R. Qu, H. Y. Qin et al., “Research progress of TGF-β/Smads signaling pathway and wound healing,” Chinese Journal of Medical Aesthetics & Cosmetology, vol. 20, no. 2, pp. 154–156, 2014. View at Google Scholar
  10. C. N. Bernstein, J. H. Michael Fried, J. H. Krabshuis et al., “Practice guidelines for the 2010 World gastroenterology organization on the diagnosis and treatment of inflammatory bowel disease,” Chinese Journal of Gastroenterology, vol. 15, no. 9, pp. 548–558, 2010. View at Google Scholar
  11. R. Yoshikawa, Y. Nakano, L. Tao et al., “Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy,” British Journal of Cancer, vol. 98, no. 10, pp. 1670–1674, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Y. Zheng, Guiding Principle of Clinical Research on New Drugs of Chinese Medicine (Trial Implementation), China Medical Science and Technology Press, Beijing, China, 2002.
  13. Z. J. Zhang, J. M. Liu, Y. Y. Zhou et al., “Preliminary study on quality of life assessment scale,” Journal of China Yichun Medical College, vol. 12, no. 3, pp. 143–145, 2000. View at Google Scholar
  14. S. Jing, X. Y. Wang, X. Yang et al., “The expressions of TGF-β1 and SP-A in the lung and the intestines of rats with ulcerative colitis and TCM intervention on the changes,” Western Journal of Traditional Chinese Medicine, vol. 27, no. 3, pp. 10–15, 2014. View at Google Scholar
  15. D. L. Bruce and G. P. Sapkota, “Phosphatases in SMAD regulation,” FEBS Letters, vol. 586, no. 14, pp. 1897–1905, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Flentjar, P.-Y. Chu, A. Y.-N. Ng et al., “TGF-βRII rescues development of small intestinal epithelial cells in Elf3-deficient mice,” Gastroenterology, vol. 132, no. 4, pp. 1410–1419, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Attisano and J. L. Wrana, “Smads as transcriptional co-modulators,” Current Opinion in Cell Biology, vol. 12, no. 2, pp. 235–243, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Zhang, H. Huang, Y. Y. Huang et al., “Expression and clinical significance of TGF-β1 and Smad4 in colorectal carcinoma,” Youjiang Medical Journal, vol. 38, no. 1, pp. 10–11, 2010. View at Google Scholar
  19. J. P. Xing and N. Chen, “Smad and renal fibrosis,” Chinese Journal of Integrated Traditional and Western Nephrology, vol. 5, no. 6, pp. 302–304, 2005. View at Google Scholar
  20. S. Itoh, F. Itoh, M.-J. Goumans, and P. T. Dijke, “Signaling of transforming growth factor-β family members through Smad proteins,” European Journal of Biochemistry, vol. 267, no. 24, pp. 6954–6967, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Z. Li and Q. Li, “TGF-β/Smads Signaling pathway and its role in tumor,” Medical Review, vol. 17, no. 6, pp. 847–849, 2011. View at Google Scholar
  22. Y. Chen, Y. Xiao, W. Ge et al., “MiR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells,” Cell Death and Disease, vol. 4, no. 3, p. e541, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Zheng, M. H. Zhu, and C. R. Ni, “Expression of TGF-β/Smads signaling pathway related proteins in pancreatic intraepithelial neoplasia and pancreatic cancer tissues,” Journal of Clinical and Experimental Pathology, vol. 20, no. 3, pp. 327–331, 2005. View at Google Scholar
  24. I. Marafini, F. Zorzi, S. Codazza, F. Pallone, and G. Monteleone, “TGF-beta signaling manipulation as potential therapy for IBD,” Current Drug Targets, vol. 14, no. 12, pp. 1400–1404, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Y. Xu, S. Y. Gu, and J. Wang, “Study on the relationship between TGF-β1 and ulcerative colitis,” Practical Integrated Chinese and Western Medicine, vol. 13, no. 7, pp. 1–3, 2013. View at Google Scholar
  26. X. Guo and X.-F. Wang, “Signaling cross-talk between TGF-β/BMP and other pathways,” Cell Research, vol. 19, no. 1, pp. 71–88, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Shi and J. Massagué, “Mechanisms of TGF-β signaling from cell membrane to the nucleus,” Cell, vol. 113, no. 6, pp. 685–700, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Marafini, F. Zorzi, S. Codazza, F. Pallone, and G. Monteleone, “TGF-β signaling manipulation as potential therapy for IBD,” Current Drug Targets, vol. 14, no. 12, pp. 1400–1404, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Y. Xia and X. M. Wang, “Study of TGF-β1 in tumor,” Modern Oncology Medicine, vol. 3, no. 22, pp. 710–712, 2014. View at Google Scholar
  30. C. S. Hill, “Nucleocytoplasmic shuttling of Smad proteins,” Cell Research, vol. 19, no. 1, pp. 36–46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. C.-H. Heldin and A. Moustakas, “Role of Smads in TGFβ signaling,” Cell and Tissue Research, vol. 347, no. 1, pp. 21–36, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Miyazono, “Positive and negative regulation of TGF-β signaling,” Journal of Cell Science, vol. 113, no. 7, pp. 1101–1109, 2000. View at Google Scholar · View at Scopus
  33. A. W. Taylor, “Review of the activation of TGF-β in immunity,” Journal of Leukocyte Biology, vol. 85, no. 1, pp. 29–33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Masamune and T. Shimosegawa, “Signal transduction in pancreatic stellate cells,” Journal of Gastroenterology, vol. 44, no. 4, pp. 249–260, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Y. Lan and A. C. K. Chung, “Transforming growth factor-β and smads,” Contributions to Nephrology, vol. 170, pp. 75–82, 2011. View at Publisher · View at Google Scholar · View at Scopus