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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 2674014, 17 pages
http://dx.doi.org/10.1155/2016/2674014
Review Article

An Analysis of the Combination Frequencies of Constituent Medicinal Herbs in Prescriptions for the Treatment of Stroke in Korean Medicine: Determination of a Group of Candidate Prescriptions for Universal Use

1Division of Humanities and Social Medicine, School of Korean Medicine, Pusan National University, Yangsan 626-870, Republic of Korea
2Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan 626-870, Republic of Korea

Received 15 December 2015; Revised 21 February 2016; Accepted 22 February 2016

Academic Editor: Shan-Yu Su

Copyright © 2016 Byeong Cheol Yun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Breinbauer, M. Manger, M. Scheck, and H. Waldmann, “Natural product guided compound library development,” Current Medicinal Chemistry, vol. 9, no. 23, pp. 2129–2145, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. F. E. Koehn and G. T. Carter, “The evolving role of natural products in drug discovery,” Nature Reviews Drug Discovery, vol. 4, no. 3, pp. 206–220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. T. W. Corson and C. M. Crews, “Molecular understanding and modern application of traditional medicines: triumphs and trials,” Cell, vol. 130, no. 5, pp. 769–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Zhang, Y. Li, X. Guo et al., “Text mining of the classical medical literature for medicines that show potential in diabetic nephropathy,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 189125, 12 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. Choi, B. T. Choi, H. K. Shin, B. C. Shin, Y. K. Han, and J. U. Baek, “Establishment of a comprehensive list of candidate anti-aging medicinal herb used in Korean medicine by text mining of the classical Korean medical literature, ‘Dongeuibogam’, and preliminary evaluation of the anti-aging effects of these herb,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 873185, 29 pages, 2015. View at Publisher · View at Google Scholar
  6. S. Li, “Network systems underlying traditional Chinese medicine syndrome and herb formula,” Current Bioinformatics, vol. 4, no. 3, pp. 188–196, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. N. J. Sucher, “The application of Chinese medicine to novel drug discovery,” Expert Opinion on Drug Discovery, vol. 8, no. 1, pp. 21–34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Jia, W.-Y. Gao, Y.-Q. Yan et al., “The rediscovery of ancient Chinese herbal formulas,” Phytotherapy Research, vol. 18, no. 8, pp. 681–686, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. B. Scholey and D. O. Kennedy, “Acute, dose-dependent cognitive effects of Ginkgo biloba, Panax ginseng and their combination in healthy young volunteers: differential interactions with cognitive demand,” Human Psychopharmacology: Clinical and Experimental, vol. 17, no. 1, pp. 35–44, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. J. U. Baek and B. W. Lee, “A study on the frequencies of medicinal herb combinations in the prescriptions of ‘Bangyakhappyeon’,” Journal of Korean Medical Classics, vol. 24, no. 4, pp. 55–67, 2011. View at Google Scholar
  11. J. U. Baek, S. W. Shin, and B. W. Lee, “A study on the frequencies of medicinal herb combinations in the prescriptions of ‘Wenbingtiaobian’,” Korean Journal of Oriental Medicine, vol. 17, no. 3, pp. 61–68, 2011. View at Google Scholar
  12. J. U. Baek, S. W. Shin, and B. W. Lee, “Study on the frequencies of medicinal herb combinations in the prescriptions of ‘Wenrejingwei’,” Korean Journal of Oriental Physiology & Pathology, vol. 25, no. 5, pp. 759–764, 2011. View at Google Scholar
  13. Y. T. Oh, S. C. Kim, and B. W. Lee, “Estimation study of the herbal formula's effects by the compositional herbal effects (guideline of the herbal effects intensity),” Journal of Korean Medical Classics, vol. 21, no. 2, pp. 49–57, 2008. View at Google Scholar
  14. K. R. Park, A bibliographic study on Donguibogam [Doctorate Thesis], Graduate School, Chonnam National University, Gwangju, South Korea, 2009.
  15. O. M. Kwon, W. S. Cha, S. Y. Park, J. H. Oh, and S. W. Ahn, “The appropriation of donguibogam and bencaogangmu and the shaping of distinctive Korean medicine in the late joseon dynasty,” Korean Journal of Oriental Medicine, vol. 17, no. 3, p. 17, 2011. View at Google Scholar
  16. Z. Zhang, R. Zhao, J. Qi, S. Wen, Y. Tang, and D. Wang, “Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons,” Journal of Neuroscience Research, vol. 89, no. 3, pp. 437–447, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J. S. Cho, C. H. Yang, and C. G. Park, “Inhibition of excitotoxic neuronal cell death by total extracts from oriental medicines used for stroke treatment,” YakhakHoeji, vol. 44, no. 1, pp. 29–35, 2000. View at Google Scholar
  18. A. Li, L. Han, and C. C. Han, “Antioxidant and neuroprotective activities of essential oil, isolated from chinese herb pairs of Angelica sinensis and Sophora flavescens,” Journal of Applied Pharmaceutical Science, vol. 2, no. 5, pp. 1–4, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J. C. Singh, R. M. Kakalij, R. P. Kshirsagar, B. H. Kumar, S. S. Komakula, and P. V. Diwan, “Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice,” Pharmaceutical Biology, vol. 53, no. 5, pp. 630–636, 2014. View at Publisher · View at Google Scholar
  20. Q. Zhou, W. Liao, and W. Yang, “Comparison of effects between angelica sinensis and sodium ferulate on neurological function after reperfusion of focal cerebral ischemia in rats,” Medical Journal of Wuhan University, vol. 28, no. 3, pp. 332–340, 2007. View at Google Scholar · View at Scopus
  21. X. Hu, W. Liao, W. Yang, C. Jiang, Q. Zhou, and M. Cheng, “Effects of angelica polysaccharide on the expression of angiopoietin after the ischemic brain injury in rats,” Chinese Journal of Rehabilitation Medicine, vol. 21, no. 3, pp. 204–206, 2006. View at Google Scholar
  22. W.-J. Liao, M. Fan, Y.-H. Yang, W.-T. Yang, L.-Y. Li, and M.-L. Liu, “Effects of Angelica sinensis injection on the neuronal metabolites and blood flow speed within reperfusion following the ischemic cerebral injury in rats,” Chinese Journal of Applied Physiology, vol. 19, no. 3, pp. 209–212, 2003. View at Google Scholar · View at Scopus
  23. L. Meng, W. Liao, W. Yang, C. Zheng, and C. Jiang, “Effects of angelica sinensis on the angiogenesis after reperfusion of the ischemia brain injury in rats,” Chinese Journal of Rehabilitation Medicine, vol. 20, no. 2, pp. 84–86, 2005. View at Google Scholar
  24. C. J. Zheng, W. J. Liao, M. Fan, W. T. Yang, and L. Q. Meng, “Effects of Angelica sinensis treatment on the expression of flt-1 and flk-1 mRNA after the ischemic brain injury in rats,” Zhongguo Ying Yong Sheng Li Xue Za Zhi, vol. 22, no. 4, pp. 385–389, 2006. View at Google Scholar
  25. C.-Y. Cheng, T.-Y. Ho, E.-J. Lee, S.-Y. Su, N.-Y. Tang, and C.-L. Hsieh, “Ferulic acid reduces cerebral infarct through its antioxidative and anti-Inflammatory effects following transient focal cerebral ischemia in rats,” The American Journal of Chinese Medicine, vol. 36, no. 6, pp. 1105–1119, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. S. A. Gim, J. H. Sung, F. A. Shah, M. O. Kim, and P. O. Koh, “Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model,” Laboratory Animal Research, vol. 29, no. 2, pp. 63–69, 2013. View at Publisher · View at Google Scholar
  27. Z. Feng, Y. Lu, X. Wu et al., “Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion,” Journal of Ethnopharmacology, vol. 144, no. 2, pp. 313–321, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-Y. Peng, J.-R. Du, G.-Y. Zhang et al., “Neuroprotective effect of Z-Ligustilide against permanent focal ischemic damage in rats,” Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 309–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Boo, S. Park, Y. Yu et al., “Neuroprotective Effects of Angelica gigas NAKAI on transient focal cerebral ischemia in rats: involvement of antioxidative effects and cyclooxygenase-2 inhibition,” Journal of Cerebral Blood Flow & Metabolism, vol. 23, p. 443, 2003. View at Google Scholar
  30. X. Kuang, Y. Yao, J. R. Du, Y. X. Liu, C. Y. Wang, and Z. M. Qian, “Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice,” Brain Research, vol. 1102, no. 1, pp. 145–153, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Kuang, J.-R. Du, Y.-X. Liu, G.-Y. Zhang, and H.-Y. Peng, “Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats,” Pharmacology Biochemistry and Behavior, vol. 88, no. 3, pp. 213–221, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Luo, X. Wang, H. Su, and L. Zhu, “Protection of Angelica sinensis volatile oil on focal cerebral ischemia-reperfusion in rats,” Latin American Journal of Pharmacy, vol. 33, no. 5, pp. 771–777, 2014. View at Google Scholar · View at Scopus
  33. D. Chen, J. Tang, N. H. Khatibi et al., “Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 337, no. 3, pp. 663–672, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Peng, P. Zhao, Y.-P. Lu et al., “Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro,” Brain Research, vol. 1520, pp. 168–177, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. B. K. Song, Y. C. Jeon, S. A. Kim, A. N. Shim, K. M. Seong, and E. J. Lee, “The effect of intravenous injection of the water extract of Angelica gigas nakai on gliosis in the middle cerebral artery occlusion rats,” Journal of Pharmacopuncture, vol. 14, no. 3, pp. 5–17, 2011. View at Publisher · View at Google Scholar
  36. Y.-L. Jeon, C.-S. Park, and C.-G. Park, “An experimental study of effect on brain damage and neuroprotective effect of angelicae gigantis radix extract against cerebral ischemia in rats,” The Korea Journal of Herbology, vol. 18, no. 4, pp. 25–35, 2003. View at Google Scholar
  37. J. O. Jeong, W. K. Jang, Y. S. Oh, S. Y. Lee, C. S. Park, and C. G. Park, “The neuroprotective effects of angelicae gigantis radix on focal cerebral ischemia in the rat,” Journal of Korean Oriental Medicine, vol. 24, no. 2, pp. 204–212, 2003. View at Google Scholar
  38. Y. O. Kim, N. N. Ha, Y. M. Boo et al., “Neuroprotective effect of Angelica gigas extracts on the brain ischemia induced by four-vessel occlusion in rats,” The Korea Journal of Herbology, vol. 17, pp. 151–157, 2002. View at Google Scholar
  39. T. W. Oh, K. H. Park, M. Y. Lee et al., “Neuroprotective effects of Angelicae acutilobae Radix water extract against ischemia, reperfusion-induced apoptosis in SK-N-SH neuronal cells,” The Korea Journal of Herbology, vol. 26, no. 4, pp. 67–74, 2011. View at Google Scholar
  40. K.-H. Park, T.-W. Oh, and Y.-K. Park, “Neuroprotective effect of the water extract of Angelicae Gigantis Radix Palva in ischemic stroke rats,” The Korea Journal of Herbology, vol. 27, no. 2, pp. 61–67, 2012. View at Publisher · View at Google Scholar
  41. Y. J. Shin and Y. K. Park, “Effects of different parts of Angelica gigas Nakai on brain damages and neuronal death in transient middle artery occlusion/reperfusion-induced ischemic rats,” The Korea Journal of Herbology, vol. 29, no. 6, pp. 85–93, 2014. View at Publisher · View at Google Scholar
  42. Y.-M. Liu, J.-J. Zhang, and J. Jiang, “Observation on clinical effect of Angelica injection in treating acute cerebral infarction,” Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi, vol. 24, no. 3, pp. 205–208, 2004. View at Google Scholar · View at Scopus
  43. Y.-C. Wu and C.-L. Hsieh, “Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction,” Chinese Medicine, vol. 6, no. 1, pp. 32–36, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. W. S. Yun, H. H. Kim, D. K. Ahn, J. S. Rhee, I. H. Ham, and H. Y. Choi, “Effects of angelicaekoreanae radix on the vasomotor responses and focal cerebral ischemic damage by MCAO,” The Korea Journal of Herbology, vol. 19, no. 3, pp. 147–154, 2004. View at Google Scholar
  45. S. W. Choi, Y. J. Chae, Y. S. Kim, Y. K. Min, B. T. Kim, and W. G. Lee, “Poster session: chemical genomics and drug discovery; SA-61, a polyacetylene compound from rhizome of atractylodes japonica, inhibits the hypoxia signaling pathway by reducing HIF-1a expression,” in Proceedings of the Spring Scientific Meeting and General Assembly of the Biochemical Society of the Republic of Korea, p. 348, 2007.
  46. W.-X. Hu, Q. Xiang, Z. Wen, D. He, X.-M. Wu, and G.-Z. Hu, “Neuroprotective effect of Atractylodes macrocephalaon polysaccharides in vitro on neuronal apoptosis induced by hypoxia,” Molecular Medicine Reports, vol. 9, no. 6, pp. 2573–2581, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. N.-K. Huang, Y. Chern, J.-M. Fang, C.-I. Lin, W.-P. Chen, and Y.-L. Lin, “Neuroprotective principles from Gastrodia elata,” Journal of Natural Products, vol. 70, no. 4, pp. 571–574, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. C.-F. Tsai, C.-L. Huang, Y.-L. Lin, Y.-C. Lee, Y.-C. Yang, and N.-K. Huang, “The neuroprotective effects of an extract of Gastrodia elata,” Journal of Ethnopharmacology, vol. 138, no. 1, pp. 119–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. X. Zeng, Y. Zhang, S. Zhang, and X. Zheng, “A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus,” Biological and Pharmaceutical Bulletin, vol. 30, no. 4, pp. 801–804, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. P. R. Seok, S. J. Oh, J. W. Choi et al., “Effects of Gastrodia elata Blume on the focal brain injury induced by middle cerebral artery occlusion/reperfusion in rats,” in Proceedings of the KALAS International Symposium, p. 192, Jejudo, South Korea, August 2013.
  51. S. J. Lee, Effects of p-hydroxybenzyl alcohol and forced exercise on rat stroke model [M.S. thesis], Graduate School, Inje, South Korea, 2009.
  52. H.-J. Kim, S.-R. Lee, and K.-D. Moon, “Ether fraction of methanol extracts of Gastrodia elata, medicinal herb protects against neuronal cell damage after transient global ischemia in gerbils,” Phytotherapy Research, vol. 17, no. 8, pp. 909–912, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. S. J. Yu, J. R. Kim, C. K. Lee et al., “Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions,” Biological and Pharmaceutical Bulletin, vol. 28, no. 6, pp. 1016–1020, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. S. S. Yu, J. Zhao, W. P. Zheng, and Y. Zhao, “Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats,” Brain Research, vol. 1308, pp. 167–175, 2010. View at Publisher · View at Google Scholar
  55. K.-Y. Kam, S. J. Yu, N. Jeong et al., “p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia,” Molecules and Cells, vol. 31, no. 3, pp. 209–215, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. X. F. Li, Y. K. Sun, W. M. Zhang, X. H. Duan, R. Dai, and Q. Lin, “Protective effect of esterified phenolic compounds from Gastrodia elata Blume. on cerebral ischemia-reperfusion injury,” Natural Product Research & Development, vol. 23, no. 5, pp. 842–845, 2011. View at Google Scholar
  57. P. R. Seok, The protective effects of Gastrodiaelata Blume extracts on the middle cerebral artery occlusion in rats [M.S. thesis], Graduate School, Eulji University, 2014.
  58. H. J. Kim, I. K. Hwang, and M. H. Won, “Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia,” Brain Research, vol. 1181, no. 1, pp. 130–141, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. H. C. Kim and D. K. Ahn, “Neuroprotective effect of gastrodiaerhizoma on global ischemia induced by 4-vessel occlusion in rats,” The Korea Journal of Herbology, vol. 14, no. 1, pp. 121–129, 1999. View at Google Scholar
  60. Y. S. Younand and J. S. Lee, “Effect of gastrodiaerhizoma on apoptosis in cerebral infarction induced by middle cerebral artery occlusion in rats,” Journal of Oriental Rehabilitation Medicine, vol. 19, no. 3, pp. 1–13, 2009. View at Google Scholar
  61. J. H. Lee, The inhibitory effects of the extracts, p-hydroxybenzyl alcohol and p-hydroxybenzaldehyde of Gastrodiaelatablume on brain damage in rat ischemic model [Ph.D. thesis], Graduate School, Inje University, 2005.
  62. S.-Y. Su and C.-L. Hsieh, “Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia,” Chinese Medicine, vol. 6, no. 1, pp. 26–34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. E. Behravan, B. M. Razavi, and H. Hosseinzadeh, “Review of plants and their constituents in the therapy of cerebral ischemia,” Phytotherapy Research, vol. 28, no. 9, pp. 1265–1274, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. J. Zhang, Y. Li, X. Chen, Y. Pan, S. Zhang, and Y. Wang, “Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention,” PLoS ONE, vol. 9, no. 8, Article ID e102506, 17 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  65. S.-W. Kim, Y. Jin, J.-H. Shin et al., “Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion,” Neurobiology of Disease, vol. 46, no. 1, pp. 147–156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. X.-Q. Yu, C. C. Xue, Z.-W. Zhou et al., “In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice),” Life Sciences, vol. 82, no. 1-2, pp. 68–78, 2008. View at Publisher · View at Google Scholar · View at Scopus
  67. Y.-X. Sun, Y. Tang, A.-L. Wu et al., “Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties,” Journal of Asian Natural Products Research, vol. 12, no. 12, pp. 1051–1060, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. I.-K. Hwang, S.-S. Lim, K.-H. Choi et al., “Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia,” Acta Pharmacologica Sinica, vol. 27, no. 8, pp. 959–965, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. C. Zhan and J. Yang, “Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats,” Pharmacological Research, vol. 53, no. 3, pp. 303–309, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. J. Ling, W. Deng, J. Zhang, X. Li, and F. Yang, “Effect of chuangxiong oil on ICAM-1 ,TNF -α and ET in focal cerebral ischemiaμreperfusion rat,” Pharmacology and Clinics of Chinese Materiamedica, vol. 24, no. 4, pp. 32–34, 2008. View at Google Scholar
  71. J.-W. Tian, F.-H. Fu, W.-L. Jiang, C.-Y. Wang, F. Sun, and T.-P. Zhang, “Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action,” China Journal of Chinese Materia Medica, vol. 30, no. 6, pp. 466–468, 2005. View at Google Scholar · View at Scopus
  72. J. Ling, W. Deng, J. Zhang, and F. Yang, “The protective effect of Chuanxiong Oil on focal cerebral reperfusion injury in rat,” Pharmacology and Clinics of Chinese Materiamedica, vol. 24, no. 1, pp. 39–41, 2008. View at Google Scholar
  73. I. S. Baeg, C. S. Park, and C. G. Park, “The effects of Cnidium officinale extract on the ischemic stroke and oxidative neural damage in rats' brain,” The Korea Journal of Herbology, vol. 18, no. 4, pp. 37–46, 2003. View at Google Scholar
  74. J. Yang, X. Bie, and H. Liu, “40 Cases of stroke seqeula treated with chuanxiong extraction by acupoint application,” China Journal of Basic Medicine in Traditional Chinese Medicine, vol. 10, no. 3, pp. 62–63, 2004. View at Google Scholar
  75. D. R. Chen, “Comparative study of chuanxiong and dextran 40 in the treatment of acute cerebral infarction,” Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi, vol. 12, no. 2, pp. 71–67, 1992. View at Google Scholar · View at Scopus
  76. K. J. Chen and K. Chen, “Ischemic stroke treated with Ligusticum chuanxiong,” Chinese Medical Journal, vol. 105, no. 10, pp. 870–873, 1992. View at Google Scholar · View at Scopus
  77. X. He, D. Xing, Y. Ding, Y. Li, L. Xu, and L. Du, “Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats,” Journal of Ethnopharmacology, vol. 94, no. 2-3, pp. 339–344, 2004. View at Publisher · View at Google Scholar · View at Scopus
  78. R. Sun, L.-L. Lv, and G.-Q. Liu, “Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils,” Zhongguo Zhong Yao Za Zhi, vol. 31, no. 10, pp. 832–835, 2006. View at Google Scholar · View at Scopus
  79. L. Xiao, Y.-Z. Wang, J. Liu, X.-T. Luo, Y. Ye, and X.-Z. Zhu, “Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats,” Life Sciences, vol. 78, no. 4, pp. 413–420, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. C. Cao, X. He, W. Wang, L. Zhang, H. Lin, and L. Du, “Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract,” Biomedical Chromatography, vol. 20, no. 12, pp. 1283–1288, 2006. View at Publisher · View at Google Scholar · View at Scopus
  81. D.-Z. Liu, K.-Q. Xie, X.-Q. Ji, Y. Ye, C.-L. Jiang, and X.-Z. Zhu, “Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists,” British Journal of Pharmacology, vol. 146, no. 4, pp. 604–611, 2005. View at Publisher · View at Google Scholar · View at Scopus
  82. Y.-F. Chen, K.-J. Wu, and W. G. Wood, “Paeonia lactiflora extract attenuating cerebral ischemia and arterial intimal hyperplasia is mediated by paeoniflorin via modulation of VSMC migration and Ras/MEK/ERK signaling pathway,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 482428, 12 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  83. R.-B. Guo, G.-F. Wang, A.-P. Zhao, J. Gu, X.-L. Sun, and G. Hu, “Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses,” PLoS ONE, vol. 7, no. 11, Article ID e49701, pp. 1–11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  84. N.-N. Song, J.-B. Wu, X.-B. Wei, H.-S. Guan, and X.-M. Zhang, “Paeonol attenuates oxygen-glucose deprivation injury and inhibits NMDA receptor activation of cultured rat hippocampal neurons,” Yao Xue Xue Bao, vol. 44, no. 11, pp. 1228–1232, 2009. View at Google Scholar · View at Scopus
  85. S.-Y. Su, C.-Y. Cheng, T.-H. Tsai, and C.-L. Hsieh, “Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 932823, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  86. C.-L. Hsieh, C.-Y. Cheng, T.-H. Tsai et al., “Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats,” Journal of Ethnopharmacology, vol. 106, no. 2, pp. 208–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  87. J. Yang, J. Wang, P. Feng, Y. Li, C. Ma, and S. Xu, “Protective effect of total paeony glycoside against cerebral ischemia-reperfusion injury in mice,” Zhong yao cai, vol. 23, no. 2, pp. 95–97, 2000. View at Google Scholar · View at Scopus
  88. R.-Q. Ma, J.-W. Chen, J.-X. Pang, X.-J. Lan, and C.-H. Qiu, “Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils,” Di Yi Jun Yi Da XueXueBao, vol. 25, no. 4, pp. 471–473, 2005. View at Google Scholar · View at Scopus
  89. J. Yang, J. Wang, and C. Liu, “Protective effects of total paeony glycoside on cerebral ischemia mice,” Zhong yao cai, vol. 24, no. 2, pp. 124–126, 2001. View at Google Scholar · View at Scopus
  90. N.-Y. Tang, C.-H. Liu, C.-T. Hsieh, and C.-L. Hsieh, “The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in sprague-dawley rats,” American Journal of Chinese Medicine, vol. 38, no. 1, pp. 51–64, 2010. View at Publisher · View at Google Scholar · View at Scopus
  91. R. Fattorusso, S. Frutos, X. Sun, N. J. Sucher, and M. Pellecchia, “Traditional Chinese medicines with caspase-inhibitory activity,” Phytomedicine, vol. 13, no. 1-2, pp. 16–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
  92. H. J. Lee, U. Koo, H. J. Lee, D. H. Lee, and W. C. Mar, “Neuroprotective effects of some plant extracts against oxygen-glucose deprivation (OGD)-induced oxidative cell death on neuronal cell,” Korean Journal of Medicinal Crop Science, vol. 17, no. 5, pp. 341–345, 2009. View at Google Scholar
  93. Y. Li, Y. Bao, B. Jiang et al., “Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage,” International Journal of Developmental Neuroscience, vol. 26, no. 3-4, pp. 309–317, 2008. View at Publisher · View at Google Scholar · View at Scopus
  94. Y. Liu, Q. Xue, X. Li et al., “Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin,” International Journal of Biological Sciences, vol. 10, no. 4, pp. 448–456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  95. D.-Q. Li, Y. Li, Y. Liu, Y.-M. Bao, B. Hu, and L.-J. An, “Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury,” Toxicon, vol. 46, no. 8, pp. 845–851, 2005. View at Publisher · View at Google Scholar · View at Scopus
  96. H.-F. Zhu, D. Wan, Y. Luo, P. Xie, and X.-Y. Xu, “Catalpol up-regulated GAP-43 protein expression and improved behavior outcome of focal cerebral ischemia rats,” Chinese Pharmacological Bulletin, vol. 23, no. 9, pp. 1231–1236, 2007. View at Google Scholar · View at Scopus
  97. X. Sun, L. N. Chan, X. Gong, and N. J. Sucher, “N-methyl-D-aspartate receptor antagonist activity in traditional Chinese stroke medicines,” Neuro-Signals, vol. 12, no. 1, pp. 31–38, 2003. View at Publisher · View at Google Scholar · View at Scopus
  98. J. Dai, L. Chen, Y.-M. Qiu et al., “Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin's neuroprotection against gerbil global ischemia/reperfusion injury,” Brain Research Bulletin, vol. 90, no. 1, pp. 1–9, 2013. View at Publisher · View at Google Scholar · View at Scopus
  99. Z. Zhang, R. Wu, P. Li et al., “Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study,” Neurochemistry International, vol. 54, no. 8, pp. 488–496, 2009. View at Publisher · View at Google Scholar · View at Scopus
  100. X. Xue, X.-J. Qu, Y. Yang et al., “Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation,” Biochemical and Biophysical Research Communications, vol. 403, no. 3-4, pp. 398–404, 2010. View at Publisher · View at Google Scholar · View at Scopus
  101. Y. Cao, X. Mao, C. Sun et al., “Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways,” Brain Research Bulletin, vol. 85, no. 6, pp. 396–402, 2011. View at Publisher · View at Google Scholar · View at Scopus
  102. M. Xu, X. Chen, Y. Gu et al., “Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury,” Journal of Ethnopharmacology, vol. 150, no. 1, pp. 116–124, 2013. View at Publisher · View at Google Scholar · View at Scopus
  103. Y. O. Kim, K. Leem, J. Park et al., “Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia,” Journal of Ethnopharmacology, vol. 77, no. 2-3, pp. 183–188, 2001. View at Publisher · View at Google Scholar · View at Scopus
  104. Y.-Z. Shang, H. Miao, J.-J. Cheng, and J.-M. Qi, “Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats,” Biological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 805–810, 2006. View at Publisher · View at Google Scholar · View at Scopus
  105. Y. Z. Shang, H. Zhang, J. J. Cheng et al., “Flavonoids from scutellaria baicalensis georgi are effective to treat cerebral ischemia/reperfusion,” Neural Regeneration Research, vol. 8, no. 6, pp. 514–522, 2013. View at Publisher · View at Google Scholar · View at Scopus
  106. Y. Shang, G. Miao, H. Zhao et al., “Mechanisms underlying attenuation of apoptosis of cortical neurons in the hypoxic brain by flavonoids from the stems and leaves of Scutellaria baicalensis Georgi,” Neural Regeneration Research, vol. 9, no. 17, pp. 1592–1598, 2014. View at Publisher · View at Google Scholar
  107. H. Y. Kwon, Neuroprotective effect of baicalein in experimental ischemia-reperfusion brain injury [Ph.D. thesis], Grateduate School Chungbuk University, 2011.
  108. J. S. Cho and H. K. Lee, “Neuroprotective effect of woganin in a rodent model of permanent focal cerebral ischemia,” Proceedings of the Convention of the Pharmaceutical Society of Korea, vol. 2, no. 10, pp. 303.2–303.3, 2002. View at Google Scholar
  109. S. M. Zhao, W. Kong, S. F. Zhang, M. Chen, X. Y. Zheng, and X. Y. Kong, “Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury,” Neural Regeneration Research, vol. 8, no. 34, pp. 3183–3192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  110. X. Y. Kong, W. Kong, G. X. Miao et al., “Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/ reperfusion injury in hippocampal neurons,” Neural Regeneration Research, vol. 9, no. 23, pp. 2066–2073, 2014. View at Publisher · View at Google Scholar · View at Scopus
  111. Y. Zhang, X. Wang, X. Wang et al., “Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury,” Journal of Ethnopharmacology, vol. 108, no. 3, pp. 355–360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  112. L.-Y. Liu, E.-Q. Wei, Y.-M. Zhao et al., “Protective effects of baicalin on oxygen/glucose deprivation- and NMDA-induced injuries in rat hippocampal slices,” Journal of Pharmacy and Pharmacology, vol. 57, no. 8, pp. 1019–1025, 2005. View at Publisher · View at Google Scholar · View at Scopus
  113. Y. O. Kim, J. Y. Park, K. H. Joe et al., “Scutellaria baicalensis protects CA1 hippocampal neurons after global cerebral ischemia in rats,” Proceedings of the Convention of the Pharmaceutical Society of Korea, vol. 2000, no. 4, pp. 141.2–141.3, 2000. View at Google Scholar
  114. Y. Shang, J. Cheng, J. Qi, and H. Miao, “Scutellaria flavonoid reduced memory dysfunction and neuronal injury caused by permanent global ischemia in rats,” Pharmacology Biochemistry and Behavior, vol. 82, no. 1, pp. 67–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  115. J.-H. Lee and S.-R. Lee, “The effect of baicalein on hippocampal neuronal damage and metalloproteinase activity following transient global cerebral ischaemia,” Phytotherapy Research, vol. 26, no. 11, pp. 1614–1619, 2012. View at Publisher · View at Google Scholar · View at Scopus
  116. J. E. Park and Y. K. Kim, “The effect of scutellariae radix on ischemia induced brain injury in rats,” The Korean Journal of Joongpoong, vol. 10, no. 1, pp. 8–19, 2009. View at Google Scholar
  117. J. S. Cho and H.-K. Lee, “Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion,” Biological and Pharmaceutical Bulletin, vol. 27, no. 10, pp. 1561–1564, 2004. View at Publisher · View at Google Scholar · View at Scopus
  118. B. P. Gaire, S.-K. Moon, and H. Kim, “Scutellaria baicalensis in stroke management: nature's blessing in traditional Eastern medicine,” Chinese Journal of Integrative Medicine, vol. 20, no. 9, pp. 712–720, 2014. View at Publisher · View at Google Scholar · View at Scopus