Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway

<div>Inhibition of the viability of MCF-7 cells with SSCE treatment. (a) SSCE treatment in the absence of 17β-estradiol (E2) inhibited the proliferation of MCF-7 cells. The IC50 of SSCE treated for 24 h, 48 h, and 72 h was 109 μg/ml, 102 μg/ml, and 83 μg/ml, respectively. (b) Addition of 10−8 M E2 promoted the effect of SSCE. The IC50 of SSCE in the presence of 10−8 M E2 was 81 μg/ml, 68 μg/ml, and 60 μg/ml for a 24 h, 48 h, and 72 h incubation, respectively. (c) The proliferation-related protein (PCNA) level was decreased upon treatment with SSCE (80 μg/ml, 160 μg/ml, and 320 μg/ml) for 24 h compared to control.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway