Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro

Table 1

Concentration of combination drug used in inhibiting Ca²⁺ response to agonists.

Agonist	Ferulic acid (μM)	Z-ligustilide (μM)	Total concentration (μM)
WS-12	2.1	2	4
	4.2	3.9	8.1
	16.8	15.6	33.1
	33.4	31.3	64.7
ASP 7663	2.3	1.7	4
	4.6	3.4	8
	18.3	13.7	32
	36.5	27.3	63.8