Research Article
Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I)
Table 5
Changes in fertility and pregnancy outcome in female rats.
| Terms | Vehicle control group | Positive control group | Zishen Yutai Pill-treated groups | Low dose-treated group | Moderate dose-treated group | High dose-treated group |
| Abnormal viscera () | 0 | 0 | 0 | 0 | 0 | Total weight of the gravid uterus (g) | 11.4 ± 1.6 | 11.0 ± 2.2 | 11.2 ± 1.2 | 10.5 ± 1.6 | 11.1 ± 2.6 | Ovary weight (g) | 0.16 ± 0.02 | 0.16 ± 0.02 | 0.16 ± 0.03 | 0.15 ± 0.02 | 0.15 ± 0.02 | Uterine weight (g) | 2.52 ± 0.31 | 2.38 ± 0.40 | 2.60 ± 0.26 | 2.41 ± 0.41 | 2.53 ± 0.54 | Estrous cycle (d) | | | | | | 5 d before treatment | | | | | | Diestrus | 3.28 ± 0.61 | 3.32 ± 0.80 | 2.96 ± 0.84 | 3.20 ± 0.82 | 3.16 ± 0.90 | Proestrus | 0.44 ± 0.51 | 0.52 ± 0.65 | 0.48 ± 0.65 | 0.48 ± 0.51 | 0.40 ± 0.50 | Estrus | 0.88 ± 0.78 | 0.64 ± 0.64 | 0.80 ± 0.76 | 0.72 ± 0.68 | 0.80 ± 0.76 | Postestrus | 0.44 ± 0.51 | 0.52 ± 0.51 | 0.72 ± 0.46 | 0.60 ± 0.58 | 0.64 ± 0.57 | 14 d after treatment | | | | | | Diestrus | 13.04 ± 2.96 | 11.96 ± 3.23 | 12.44 ± 1.50 | 12.28 ± 3.25 | 12.40 ± 3.03 | Proestrus | 1.60 ± 1.38 | 2.04 ± 0.98 | 1.76 ± 0.93 | 2.12 ± 1.27 | 2.12 ± 1.30 | Estrus | 0.96 ± 0.79 | 1.56 ± 1.19 | 0.88 ± 0.78 | 1.16 ± 1.07 | 1.24 ± 0.93 | Postestrus | 1.44 ± 1.39 | 1.80 ± 1.22 | 1.44 ± 1.19 | 2.04 ± 1.17 | 1.88 ± 1.48 | Luteal | | | | | | Total number of lutea () | 281 | 303 | 351 | 273 | 298 | Average number of lutea () | 14.1 ± 1.3 | 13.2 ± 1.6 | 14.0 ± 1.2 | 13.0 ± 1.8 | 13.5 ± 1.8 | Preimplantation loss rate (%) | 4.6 | 7.6 | 6.6 | 6.2 | 6.4 | Implantation | | | | | | Implantation number () | 268 | 280 | 328 | 257 | 279 | Average number of implantations () | 13.4 ± 1.1 | 12.2 ± 2.4 | 13.1 ± 1.1 | 12.2 ± 1.9 | 12.7 ± 2.6 | Implantation rate (%) | 95.4 | 92.4 | 93.4 | 94.1 | 93.6 | Live fetuses | | | | | | Number of litters | 20 | 23 | 25 | 21 | 22 | Number of live fetuses () | 250 | 255 | 310 | 242 | 266 | Average number of live fetuses () | 12.5 ± 2.1 | 11.1 ± 3.5 | 12.4 ± 1.5 | 11.5 ± 2.0 | 12.1 ± 2.7 | Live fetuses rate (%) | 93.3 | 91.1 | 94.5 | 94.2 | 95.3 | Resorbed fetuses | | | | | | Number of litters () | 11 | 11 | 10 | 12 | 9 | Number of resorbed fetuses () | 18 | 25 | 18 | 15 | 13 | Resorbed fetuses rate (%) | 6.7 | 8.9 | 5.5 | 5.8 | 4.7 |
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