Research Article

Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I)

Table 5

Changes in fertility and pregnancy outcome in female rats.

TermsVehicle control group Positive control group Zishen Yutai Pill-treated groups
Low dose-treated groupModerate dose-treated groupHigh dose-treated group

Abnormal viscera ()00000
Total weight of the gravid uterus (g)11.4 ± 1.611.0 ± 2.211.2 ± 1.210.5 ± 1.611.1 ± 2.6
Ovary weight (g)0.16 ± 0.020.16 ± 0.020.16 ± 0.030.15 ± 0.020.15 ± 0.02
Uterine weight (g)2.52 ± 0.312.38 ± 0.402.60 ± 0.262.41 ± 0.412.53 ± 0.54
Estrous cycle (d)
 5 d before treatment
  Diestrus3.28 ± 0.613.32 ± 0.802.96 ± 0.843.20 ± 0.823.16 ± 0.90
  Proestrus0.44 ± 0.510.52 ± 0.650.48 ± 0.650.48 ± 0.510.40 ± 0.50
  Estrus0.88 ± 0.780.64 ± 0.640.80 ± 0.760.72 ± 0.680.80 ± 0.76
  Postestrus0.44 ± 0.510.52 ± 0.510.72 ± 0.460.60 ± 0.580.64 ± 0.57
 14 d after treatment
  Diestrus13.04 ± 2.9611.96 ± 3.2312.44 ± 1.5012.28 ± 3.2512.40 ± 3.03
  Proestrus1.60 ± 1.382.04 ± 0.981.76 ± 0.932.12 ± 1.272.12 ± 1.30
  Estrus0.96 ± 0.791.56 ± 1.190.88 ± 0.781.16 ± 1.071.24 ± 0.93
  Postestrus1.44 ± 1.391.80 ± 1.221.44 ± 1.192.04 ± 1.171.88 ± 1.48
Luteal
 Total number of lutea ()281303351273298
 Average number of lutea ()14.1 ± 1.313.2 ± 1.614.0 ± 1.213.0 ± 1.813.5 ± 1.8
 Preimplantation loss rate (%)4.67.66.66.26.4
Implantation
 Implantation number ()268280328257279
 Average number of implantations ()13.4 ± 1.112.2 ± 2.413.1 ± 1.112.2 ± 1.912.7 ± 2.6
 Implantation rate (%)95.492.493.494.193.6
Live fetuses
 Number of litters2023252122
 Number of live fetuses ()250255310242266
 Average number of live fetuses ()12.5 ± 2.111.1 ± 3.512.4 ± 1.511.5 ± 2.012.1 ± 2.7
 Live fetuses rate (%)93.391.194.594.295.3
Resorbed fetuses
 Number of litters ()111110129
 Number of resorbed fetuses ()1825181513
 Resorbed fetuses rate (%)6.78.95.55.84.7