Transcriptomics Analysis of Candida albicans Treated with Huanglian Jiedu Decoction Using RNA-seq

Table 3

Response to HLJDD of the genes involved in ergosterol biosynthesis.

Standard or systematic name in CGD	ID in GenBank	Annotation	ratio	Probability
ERG1	XP_711894.1	Squalene monooxygenase	2.13	0.95
ERG2	XP_718886.1	C-8 sterol isomerase	3.23	0.94
ERG3	XP_713577.1	C-5 sterol desaturase	1.84	0.94
ERG4	XP_717662.1	Sterol C-24 (28) reductase	−0.34	0.65
ERG5	XP_716933.1	Cytochrome P450 61	2.02	0.97
ERG6	XP_721588.1	Sterol 24-C-methyltransferase	3.33	0.97
ERG7	XP_722471.1	2,3-Oxidosqualene-lanosterol cyclase	−0.23	0.38
ERG8	XP_722678.1	Phosphomevalonate kinase	−0.01	0.03
ERG9	XP_714460.1	Squalene synthetase	−0.60	0.77
ERG10	XP_710124.1	Acetyl-CoA acetyltransferase IA	0.96	0.91
ERG11	XP_716761.1	Cytochrome P450 51	2.02	0.97
ERG12	XP_723305.1	Mevalonate kinase	0.97	0.85
ERG13	XP_716446.1	Hydroxymethylglutaryl-CoA synthase	2.30	0.97
MVD1/ERG19	XP_718960.1	Diphosphomevalonate decarboxylase	0.04	0.12
ERG24	XP_710205.1	Delta(14)-sterol reductase	2.53	0.93
ERG25	XP_713420.1	C-4 methylsterol oxidase	1.31	0.91
	XP_722703.1	C-4 methylsterol oxidase	1.02	0.92
ERG26	XP_715564.1	C-3 sterol dehydrogenase/C-4 decarboxylase	0.23	0.39
ERG27	XP_717865.1	3-Keto sterol reductase	1.67	0.90
ERG28	XP_717865.1	Hypothetical protein	0.38	0.68
HMG1	XP_713636.1	Hydroxymethylglutaryl-CoA reductase	2.36	0.96
IDI1	XP_720295.1	Isopentenyl-diphosphate delta-isomerase	−0.09	0.24
CYB5	XP_720295.1	Cytochrome b5	−0.27	0.62