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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 3257603, 12 pages
http://dx.doi.org/10.1155/2016/3257603
Research Article

A Meta-Analysis of Randomized Controlled Trials of Yiqi Yangyin Huoxue Method in Treating Diabetic Nephropathy

Jiao Ying Ou,1,2,3,4 Di Huang,1,2,3 Yan Sheng Wu,1,2,3 Lin Xu,1,2,3 Fei He,1,2,3 Hui Ling Wang,1,2,3 Li Qiang Shi,1,2,3 Qiang Wan,1,2,3 Li Qun He,1,2,3 and Jian Dong Gao1,2,3

1Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China
2TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China
3Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China
4Department of Internal Medicine, Shanghai TCM-Integrated Hospital of Shanghai University of Traditional Chinese Medicine, No. 184 Baoding Road, Shanghai 200082, China

Received 3 February 2016; Accepted 24 April 2016

Academic Editor: Kieran Cooley

Copyright © 2016 Jiao Ying Ou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The purpose of this systematic review is to evaluate the evidence of Yiqi Yangyin Huoxue Method for diabetic nephropathy. Methods. 11 electronic databases, through September 2015, were searched to identify randomized controlled trials of Yiqi Yangyin Huoxue Method for diabetic nephropathy. The quality of the included trials was assessed using the Jadad scale. Results. 26 randomized controlled trials were included in our review. Of all the included trials, most of them were considered as high quality. The aggregated results suggested that Yiqi Yangyin Huoxue Method is beneficial to diabetic nephropathy in bringing down the microalbuminuria (SMD = −0.98, 95% CI −1.22 to −0.74), serum creatinine (SMD = −0.56, 95% CI −0.93 to −0.20), beta-2 microglobulin (MD = 0.06, 95% CI 0.01 to 0.12), fasting plasma glucose (MD = −0.35, 95% CI −0.62 to −0.08), and 2-hour postprandial blood glucose (MD = 1.13, 95% CI 0.07 to 2.20), but not in decreasing blood urea nitrogen (SMD = −0.72, 95% CI −1.47 to 0.02) or 2-hour postprandial blood glucose (SMD = −0.48, 95% CI −1.01 to 0.04). Conclusions. Yiqi Yangyin Huoxue Method should be a valid complementary and alternative therapy in the management of diabetic nephropathy, especially in improving UAER, serum creatinine, fasting blood glucose, and beta-2 microglobulin. However, more studies with long follow-up are warrant to confirm the current findings.