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Year | First author | Nation | Course of disease (month) | Case (T/C) | Intervention group | Control group | Course of treatment (week) | Outcome measures | Follow-up (month) |
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2000 | Fang [34] | China | 103.2 | 50/50 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | Symptom score, FBG, UAER, and urine beta-2 microglobulin | NMT |
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2002 | Lan [35] | China | 60~120 | 40/30 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment + pancreatic kininogenase enteric-coated tablets | 4 | UAER, Symptom score | NMT |
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2002 | Fan [36] | China | 69.36 ± 24.08 | 34/31 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | Symptom score, UAER, and FBG | NMT |
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2007 | Wu [37] | China | NMT | 26/24 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 |
Symptoms, FBG, 2hPBG, and UAER | NMT |
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2008 | Si [38] | China | 220.8 | 34/32 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 3~4 | UAER, FBG, and PBG | NMT |
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2009 | Xiaochao [39] | China | 111.6 | 50/46 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | Symptom score, UAER, and blood sugar | NMT |
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2010 | Jin [40] | China | 120 | 46/42 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | Symptom score, UAER, FBG, and creatinine | NMT |
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2010 | Xiaozhou [41] | China | 158.4 | 35/34 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 12 | UAER, FBG, and creatinine | NMT |
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2011 | Hui [42] | China | 48~114 | 20/20 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 4 | UAER | NMT |
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2011 | Fang [43] | China | 134.4 | 32/32 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | FBG, 2hPBG, and UAER | NMT |
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2011 | Xiu [44] | China | 122.16~171 | 30/30 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 12 | UAER, urea nitrogen, and creatinine | NMT |
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2012 | Xianyu [45] | China | NMT | 32/28 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | FBG, 2hPBG, and UAER | NMT |
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2012 | Sheng [46] | China | 82.8~97.2 | 32/32 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | UAER, urea nitrogen, creatinine, and FBG | NMT |
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2012 | Guiying [47] | China | 100.2 | 28/27 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | Symptom score, UAER | NMT |
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2012 | Gengliang [48] | China | 72~94 | 40/40 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | UAER | NMT |
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2012 | Baowen [49] | China | 18~96 | 60/60 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 12 | FBG, UAER, urea nitrogen, and creatinine | NMT |
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2013 | Enli [50] | China | 14.75~20.06 | 30/30 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | FBG, 2hPBG, and UAER | NMT |
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2013 | Xiaomin [51] | China | 15.6~291.6 | 60/60 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment + benazepril | 8 | FBG, UAER | NMT |
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2013 | Jing [52] | China | NMT | 27/13 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment +placebo | 12 | UAER | NMT |
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2013 | Jie [53] | China | 68.4~108 | 60/60 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment + benazepril | 8 | FBG, 2hPBG | NMT |
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2013 | Xiao [54] | China | 59.04~136.68 | 34/34 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | FBG, UAER, urea nitrogen, and creatinine | NMT |
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2013 | Shijing [55] | China | 8~180 | 41/41 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | FBG, 2hPBG, UAER, urea nitrogen, and creatinine | NMT |
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2013 | Wu [56] | China | 36~204 | 32/32 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 12 | FBG, UAER, and creatinine | NMT |
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2013 | Rui [57] | China | 1~156 | 30/30 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 12 | FBG, UAER | NMT |
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2014 | Liucun [58] | China | 31.02~134.4 | 44/42 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 8 | UAER, urea nitrogen, and creatinine | NMT |
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2015 | Maoqing [59] | China | 12~180 | 39/39 | Yiqi Yangyin Huoxue + routine treatment | Routine treatment | 24 | FBG, UAER, and urea nitrogen | 2015 |
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