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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3410213, 9 pages
http://dx.doi.org/10.1155/2016/3410213
Research Article

Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

1Department of Pediatric Neurology of Korean Medicine, I-Tomato Hospital, Seoul, Republic of Korea
2College of Korean Medicine, Gachon University, Seongnam, Republic of Korea

Received 16 October 2015; Revised 28 December 2015; Accepted 7 February 2016

Academic Editor: Sunoh Kwon

Copyright © 2016 Jinsoo Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Brodie, “Diagnosing and predicting refractory epilepsy,” Acta Neurologica Scandinavica. Supplementum, vol. 181, pp. 36–39, 2005. View at Google Scholar
  2. D. M. Ijff and A. P. Aldenkamp, “Cognitive side-effects of antiepileptic drugs in children,” Handbook of Clinical Neurology, vol. 111, pp. 707–718, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. A. A. Asadi-Pooya and M. Emami, “Perception and use of complementary and alternative medicine among children and adults with epilepsy: the importance of the decision makers,” Acta Medica Iranica, vol. 52, no. 2, pp. 153–157, 2014. View at Google Scholar · View at Scopus
  4. K. Liow, E. Ablah, J. C. Nguyen et al., “Pattern and frequency of use of complementary and alternative medicine among patients with epilepsy in the midwestern United States,” Epilepsy and Behavior, vol. 10, no. 4, pp. 576–582, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. B. T. Shaikh and J. Hatcher, “Complementary and alternative medicine in Pakistan: prospects and limitations,” Evidence-Based Complementary and Alternative Medicine, vol. 2, no. 2, pp. 139–142, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. I. Sirven, J. F. Drazkowski, R. S. Zimmerman, J. J. Bortz, D. L. Shulman, and M. Macleish, “Complementary/alternative medicine for epilepsy in Arizona,” Neurology, vol. 61, no. 4, pp. 576–577, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. I. J. Kim, J. K. Kang, and S. A. Lee, “Factors contributing to the use of complementary and alternative medicine by people with epilepsy,” Epilepsy and Behavior, vol. 8, no. 3, pp. 620–624, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. C. Schachter, “Botanicals and herbs: a traditional approach to treating epilepsy,” Neurotherapeutics, vol. 6, no. 2, pp. 415–420, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Sugaya, “Cellular mechanism of seizure discharge and its normalization by a herbal mixture prescription ‘Saikokeishito-ka-Shakuyaku’ (SK),” Yakugaku Zasshi, vol. 121, no. 5, pp. 295–317, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Sugaya, T. Tsuda, E. Sugaya, M. Takato, and K. Takamura, “Effect of Chinese medicine ‘Saiko-Keishi-To’ on the abnormal bursting activity of snail neurons,” Planta Medica, vol. 34, no. 3, pp. 294–298, 1978. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Sugaya, T. Tsuda, K. Yasuda, and E. Sugaya, “Effect of Chinese herbal medicine ‘saiko-keishi-to’ on transmembrane ionic current of snail neurons,” Planta Medica, vol. 51, no. 1, pp. 60–61, 1985. View at Google Scholar · View at Scopus
  12. A. Sugaya, T. Tsuda, K. Yasuda, and M. Onozuka, “Effect of Chinese herbal medicine ‘Saiko-keishi-to’ on intracellular calcium and protein behavior during pentylenetetrazole-induced bursting activity in snail neurons,” Planta Medica, vol. 51, no. 1, pp. 2–6, 1985. View at Google Scholar · View at Scopus
  13. E. Sugaya, A. Sugaya, K. Kajiwara et al., “Cellular physiology of epileptogenic phenomena: a hint for future therapy by a herbal mixture,” Advances in Experimental Medicine and Biology, vol. 363, pp. 165–179, 1995. View at Google Scholar · View at Scopus
  14. E. Sugaya, A. Sugaya, K. Kajiwara et al., “Nervous diseases and Kampo (Japanese herbal) medicine: a new paradigm of therapy against intractable nervous diseases,” Brain and Development, vol. 19, no. 2, pp. 93–103, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Komatsu, M. Hiramatsu, H. Yokoyama, and L. J. Willmore, “Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance,” Neuroscience Letters, vol. 205, no. 3, pp. 189–192, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Nagakubo, S.-I. Niwa, N. Kumagai et al., “Effects of TJ-960 on Sternberg's paradigm results in epileptic patients,” Japanese Journal of Psychiatry and Neurology, vol. 47, no. 3, pp. 609–620, 1993. View at Google Scholar · View at Scopus
  17. Y. T. Nakane, T. Onuma, T. Kugou, T. Kumashiro, T. Okuma, and I. Akira, “Clinical utility of TJ-960 in patients with localization related epilepsy—late phase II study: multicenter, double-blind study in comparison with placebo,” Rinsho Hyoka (Clinical Evaluation), vol. 26, pp. 419–452, 1999. View at Google Scholar
  18. H. C. Kang, Y. J. Kim, D. W. Kim, and H. D. Kim, “Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience,” Epilepsia, vol. 46, no. 2, pp. 272–279, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Sharma, S. Gulati, V. Kalra, A. Agarwala, and M. Kabra, “Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy—indian experience,” Seizure, vol. 18, no. 6, pp. 446–449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Suo, J. Liao, X. Lu et al., “Efficacy and safety of the ketogenic diet in Chinese children,” Seizure, vol. 22, no. 3, pp. 174–178, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. A. T. Berg, S. F. Berkovic, M. J. Brodie et al., “Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009,” Epilepsia, vol. 51, no. 4, pp. 676–685, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. C. B. Henderson, F. M. Filloux, S. C. Alder, J. L. Lyon, and D. A. Caplin, “Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis,” Journal of Child Neurology, vol. 21, no. 3, pp. 193–198, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Lefevre and N. Aronson, “Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy,” Pediatrics, vol. 105, no. 4, article E46, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. E. G. Neal, H. Chaffe, R. H. Schwartz et al., “The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial,” The Lancet Neurology, vol. 7, no. 6, pp. 500–506, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Akita, J. Sowa, M. Makiura, H. Akamatsu, and K. Matsunaga, “Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction),” Contact Dermatitis, vol. 48, no. 6, pp. 348–349, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Furuichi, H. Hara, Y. Asano, T. Makino, and T. Shimizu, “Letter: fixed drug eruption caused by the Japanese herbal drug kakkonto,” Dermatology Online Journal, vol. 16, no. 12, p. 13, 2010. View at Google Scholar · View at Scopus
  27. D. K. Groesbeck, R. M. Bluml, and E. H. Kossoff, “Long-term use of the ketogenic diet in the treatment of epilepsy,” Developmental Medicine and Child Neurology, vol. 48, no. 12, pp. 978–981, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. E. H. Kossoff, B. A. Zupec-Kania, P. E. Amark et al., “Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group,” Epilepsia, vol. 50, no. 2, pp. 304–317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. E. P. G. Vining, P. Pyzik, J. McGrogan et al., “Growth of children on the ketogenic diet,” Developmental Medicine and Child Neurology, vol. 44, no. 12, pp. 796–802, 2002. View at Publisher · View at Google Scholar · View at Scopus