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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3606820, 9 pages
http://dx.doi.org/10.1155/2016/3606820
Research Article

Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care

1Chemical, Biological and Agricultural Research Center (CPQBA), University of Campinas, Campinas, SP, Brazil
2Biology Institute, Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, SP, Brazil
3Institute of Biosciences, Department of Biology, Sao Paulo State University, Rio Claro, SP, Brazil

Received 26 February 2016; Revised 18 May 2016; Accepted 29 August 2016

Academic Editor: Nativ Dudai

Copyright © 2016 Lais Thiemi Yamane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Brazilian forests have one of the world’s biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu’s crude extract after depigmentation with activated charcoal and macela’s essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu’s extract and macela’s essential oil obtained an anesthesia time of 83.6 (±28.5) min longer when compared with the positive control EMLA®; the same occurred with the wound healing test; the film containing the highest concentration had a higher wound contraction () compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment.