Evidence-Based Complementary and Alternative Medicine

Research Article

Glucotoxicity Induced Oxidative Stress and Inflammation In Vivo and In Vitro in Psammomys obesus: Involvement of Aqueous Extract of Brassica rapa rapifera

Table 2

(a) Variations in serum biochemical parameters in Psammomys obesus submitted to hyperglucidic diet (30% sucrose for 9 months). Effect of aqueous extract of Brassica rapa (AEBr) at 100 mg/kg for 20 consecutive days after induction of glucotoxicity. (b) Variation in insulinemia levels in Psammomys obesus submitted to hyperglucidic diet (30% sucrose during 9 months). Effect of aqueous extract of Brassica rapa (AEBr) at 100 mg/kg for 20 consecutive days after induction of glucotoxicity.

(a)


Parameters	Control	HGD	Control + AEBr	HGD + AEBr

Glycemia (g L⁻¹)	0.65 ± 0.055	1.63 ± 0.08	0.61 ± 0.045	1.27 ± 0.16
TG (g L⁻¹)	0.38 ± 0.08	3.11 ± 1.69	0.39 ± 0.09	1.09 ± 0.37
Cholesterol (g L⁻¹)	0.90 ± 0.06	6.65 ± 2.98	0.78 ± 0.12	2.08 ± 0.68
HDL-cholesterol (mmol L⁻¹)	1.89 ± 0.21	1.49 ± 0.15	1.99 ± 0.17	3.86 ± 0.39
LDL- cholesterol (mmol L⁻¹)	0.54 ± 0.26	25.82 ± 15.48	0.51 ± 0.18	0.42 ± 0.015
CPK (U L⁻¹)	4 ± 1.00	436 ± 34.02	3 ± 0.82	42.50 ± 2.12
LDH (U L⁻¹)	4 ± 2.82	82 ± 56.66	3 ± 1.21	9.00 ± 6.24
Creatine (µmol L⁻¹)	28 ± 1.41	80 ± 49.98	26 ± 0.50	7.50 ± 0.71

Data are expressed as mean ± standard deviation (SD); (). Po: Psammomys obesus, HGD: hyperglucidic diet, and HGD + AEBr: hyperglucidic diet treated with aqueous extract of Brassica rapa. denotes a statistical difference; statistically different.
(Po control + AEBr versus Po control); (Po HGD versus Po control), (Po HGD versus Po control), (Po HGD + AEBr versus Po control + AEBr); (Po HGD + AEBr versus Po HGD).

(b)


Insulinemia (UI)	Control	Control + AEBr	HGD	HGD + AEBr

T0	25.2 ± 5.58	/	24.56 ± 6.20	/
T6	24.61 ± 6.20	/	358.66 ± 43.66	/
T final	36.2 ± 1.55	30.2 ± 1.00	10.36 ± 0.68	35.95 ± 0.85

Data are expressed as mean ± standard deviation (SD); (). Po: Psammomys obesus, HGD: hyperglucidic diet, and HGD + AEBr: hyperglucidic diet treated with aqueous extract of Brassica rapa. denotes a statistical difference; statistically different.
(Po control + AEBr versus Po control); (Po HGD versus Po control); (Po HGD + AEBr versus Po control + AEBr); (Po HGD + AEBr versus Po HGD).