Research Article

Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats

Table 1

Hemodynamic assessment under sham-operated conditions.

GroupsLVSP (mmHg)LVEDP (mmHg) + (mmHg/s)
(mmHg/s)

Sham112.25 ± 5.0610.88 ± 1.134532.13 ± 177.30−3395.13 ± 254.31
Model 113.50 ± 6.7410.75 ± 1.044592.63 ± 195.67−3431.63 ± 258.17
DMF116.00 ± 6.7811.00 ± 1.314512.75 ± 159.85−3573.50 ± 226.15
LM (15 mg/kg)116.50 ± 6.1410.88 ± 1.464575.88 ± 190.90−3464.88 ± 242.18
LM (60 mg/kg)118 ± 5.2911.00 ± 1.004648.67 ± 209.13−3446.33 ± 209.13
LM (120 mg/kg)114.13 ± 7.7411.00 ± 1.854605.38 ± 220.12−3569.50 ± 274.68
LM (240 mg/kg)115.30 ± 4.2511.40 ± 1.274659.25 ± 200.57−3606.21 ± 211.73
LM (480 mg/kg)116.38 ± 9.7811.00 ± 1.314550.75 ± 199.46−3526.13 ± 234.33

Data are presented as the means SD. No significant differences were detected among groups. LVSP: left ventricular systolic pressure; LVEDP: left ventricular end-diastolic pressure; : indices of left ventricular contraction; : indices of left ventricular relaxation.