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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3830273, 9 pages
Research Article

Topical Application of TAT-Superoxide Dismutase in Acupoints LI 20 on Allergic Rhinitis

1SIBS, CAS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Research, Zhejiang Gongshang University, Hangzhou 310018, China
2Acupuncture College, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China
3College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China
4Natural Drug Discovery Group, School of Pharmacy, Queen’s University, Belfast BT9 7BL, UK

Received 13 August 2016; Accepted 12 December 2016

Academic Editor: Jae Youl Cho

Copyright © 2016 Jing-Ke Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Reactive oxygen species are products of cellular metabolism and assigned important roles in biomedical science as deleterious factors in pathologies. In fact, some studies have shown that the therapeutic benefits of taking antioxidants were limited and the potential for therapeutic intervention remains unclear. New evidences showed that ROS have some ability of intercellular transportation. For treating allergic rhinitis, as a novel intracellular superoxide quencher, TAT-SOD applied to acupoints LI 20 instead of directly to nasal cavity can be used to test that. TTA group apply TAT-SOD cream prepared by adding purified TAT-SOD to the vehicle cream to acupoints LI 20, while placebo group used the vehicle cream instead. TTN group applied the same TAT-SOD cream directly to nasal cavity three times daily. Symptom scores were recorded at baseline and days 8 and 15. For the overall efficacy rate, TTA group was 81.0%, while placebo group was 5.9% and TTN was 0%. Malondialdehyde levels decreased observably in TTA group, and superoxide dismutase, catalase, and glutathione peroxidase levels remained basically unaffected. Enzymatic scavenging of the intracellular superoxide at acupoints LI 20 proved to be effective in treating allergic rhinitis, while no improvement was observed with the placebo group and TTN group.