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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3837270, 7 pages
http://dx.doi.org/10.1155/2016/3837270
Review Article

The Applications and Features of Liquid Chromatography-Mass Spectrometry in the Analysis of Traditional Chinese Medicine

1Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
2Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China

Received 2 May 2016; Accepted 12 October 2016

Academic Editor: Nunziatina De Tommasi

Copyright © 2016 Bingyao Pang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

With increasingly improved separation of complex samples and detection of unknown material capabilities, liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in traditional Chinese medicine (TCM) research. This article describes the principles of liquid chromatography (LC) and mass spectrometry (MS) and their advantages and disadvantages in qualitative and quantitative analysis of TCM. We retrieved research literatures about the application of LC-MS in TCM published during the past five years at home and abroad. To better guide the analysis of TCM, this review mainly focuses on the applications category of LC-MS, how often different kinds of LC-MS are used, and the qualitative and quantitative ability of various LC-MS in the study of TCM.