Protective Effects of Sheng-Mai-San on Right Ventricular Dysfunction during Chronic Intermittent Hypoxia in Mice

Figure 2

Beneficial effects of SMS on CIH-induced changes of RV structure in mice. RVID was determined by ultrasound ((a), ). Dotted lines represented the interventricular septum. Histological examination of RV sections with H&E staining ((b), ). Serve vacuolization was evidenced in 28-day-CIH mice (arrows shown). Compared with CIH mice, SMS2 (5.5 g/kg) treatment prevented this injury. Magnification, ×400; scale bar, 20 μm. Myocardial ultrastructure examination in all groups by transmission electron microscopy ((c), ). Images were acquired under magnification ×5000; scale bar, 2 μm, and magnification, ×20000; scale bar, 0.5 μm. SMS successfully improved disruption or dissolution of myofilaments, disordered sarcomere and swollen mitochondria (stars shown). Values are presented as mean ± SEM.

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