Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Fig 4

Research Article

The Cholesterol-Lowering Effect of Alisol Acetates Based on HMG-CoA Reductase and Its Molecular Mechanism

Figure 4

The interaction between alisol A 24-acetate and HMG-CoA reductase. (a) Overall pattern of interaction (alisol A 24-acetate is denoted by a bar chart). (b) Hydrogen bond graph of alisol A 24-acetate and Asn658 (the hydrogen bond is denoted by a dotted line). (c) Stacking chart of alisol A 24-acetate before and after docking (the initial structure is shown in green and the structure after docking is shown in purple). (d) The initial dihedral angle of alisol A 24-acetate: angle C3–C18–C26–C28. (e) The dihedral angle of alisol A 24-acetate: angle C3–C18–C26–C28 after stacking. (f) Hydrophobic interface of the alisol A 24-acetate side chain and the peripheral amino acid residues after stacking (alisol A 24-acetate is denoted by yellow bars). (g) Hydrophilic interface of the alisol A 24-acetate side chain and the peripheral amino acid residues after stacking (alisol A 24-acetate is denoted by yellow bars).
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