Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles
Table 2
Effects of antcin K (AnK) on tissue weight, food intake, and liver lipid.
Dose (mg/kg/day)
CON
HF
HF + AnK1
HF + AnK2
HF + AnK3
HF + Feno
HF + Metf
10
20
40
250
300
Absolute tissue weight (g)
EWAT
0.531 ± 0.052
1.264 ± 0.147###
0.867 ± 0.065
0.841 ± 0.062
0.809 ± 0.058
0.603 ± 0.041
0.813 ± 0.064
MWAT
0.278 ± 0.031
0.439 ± 0.025###
0.349 ± 0.020
0.340 ± 0.013
0.332 ± 0.025
0.247 ± 0.025
0.270 ± 0.018
RWAT
0.166 ± 0.021
0.483 ± 0.064###
0.323 ± 0.039
0.339 ± 0.031
0.306 ± 0.040
0.181 ± 0.020
0.298 ± 0.027
Visceral fat
0.697 ± 0.056
1.747 ± 0.208###
1.190 ± 0.093
1.180 ± 0.106
1.154 ± 0.096
0.784 ± 0.052
1.111 ± 0.077
Skeletal muscle
0.308 ± 0.014
0.412 ± 0.045
0.395 ± 0.036
0.364 ± 0.022
0.364 ± 0.028
0.428 ± 0.026
0.380 ± 0.025
BAT
0.158 ± 0.004
0.224 ± 0.022#
0.178 ± 0.007
0.172 ± 0.010
0.175 ± 0.008
0.157 ± 0.013
0.220 ± 0.025
Liver (g)
1.003 ± 0.024
0.987 ± 0.029
0.946 ± 0.030
0.888 ± 0.019
0.883 ± 0.018
1.700 ± 0.070
0.908 ± 0.031
Spleen (g)
0.099 ± 0.006
0.094 ± 0.004
0.090 ± 0.003
0.085 ± 0.003
0.104 ± 0.007
0.084 ± 0.005
0.093 ± 0.006
Final body weight (g)
27.21 ± 0.47
30.43 ± 1.02#
28.30 ± 0.61
27.55 ± 0.72
27.48 ± 0.46
27.55 ± 0.84
27.86 ± 0.72
Weight gain (g)
1.61 ± 0.15
3.42 ± 0.24#
1.39 ± 0.81
0.70 ± 0.86
0.58 ± 0.35
0.57 ± 0.55
0.92 ± 0.08
Food intake (g/day/mouse)
2.34 ± 0.04
1.99 ± 0.04###
1.95 ± 0.05
1.92 ± 0.07
1.98 ± 0.04
1.99 ± 0.06
1.89 ± 0.04
Liver lipids
Total lipid (mg/g)
53.7 ± 2.7
95.9 ± 6.4###
73.1 ± 4.7
66.0 ± 4.8
64.5 ± 5.2
64.9 ± 5.1
65.3 ± 4.9
Triacylglycerol (μmol/g)
40.6 ± 3.9
79.3 ± 6.3###
56.3 ± 4.2
45.7 ± 3.9
45.2 ± 4.6
47.3 ± 4.6
45.4 ± 4.2
Antcin K (AnK; AnK1, AnK2, and AnK3, 10, 20, and 40 mg/kg body wt); fenofibrate (Feno, 250 mg/kg body wt); metformin (Metf, 300 mg/kg body wt); BAT, brown adipose tissue; skeletal muscle included quadriceps muscle, which contains four parts, rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis. All values are means ± SE ( = 9). and compared with the control (CON) group; , , and compared with the high-fat plus vehicle (distilled water) (HF) group. Epididymal white adipose tissue (epididymal WAT; EWAT), retroperitoneal WAT (RWAT), and mesenteric WAT (MWAT). Visceral fat represented epididymal WAT plus retroperitoneal WAT.
