Ultrastructural Changes and Death of Leishmania infantum Promastigotes Induced by Morinda citrifolia Linn. Fruit (Noni) Juice Treatment

Table 1

Activity against promastigotes and intracellular amastigotes of Leishmania infantum, cytotoxicity in peritoneal macrophages from BALB/c and selectivity index of Morinda citrifolia fruit extract treatment and amphotericin B.

Compounds	IC50 (µg/mL)		CC50	SI
	Promastigote	Intracellular amastigote	J774.G8
Morinda citrifolia fruit juice	260.5 ± 0.044	201.3 ± 0.175	>2000	>9.9
Amphotericin B	3.1 ± 0.230	0.9 ± 0.121	2.7 ± 0.156	3.0

IC₅₀: inhibitory concentration of 50% parasites. CC₅₀: cytotoxicity concentration of 50% cells. SI: selectivity index. Data are presented as the mean ± SD of three independent experiments realized at least in triplicate.