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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 5365291, 11 pages
http://dx.doi.org/10.1155/2016/5365291
Research Article

Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats

1Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China
2Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China

Received 24 May 2016; Accepted 14 November 2016

Academic Editor: Ho Lin

Copyright © 2016 Lihong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Morinda officinalis is a traditional Chinese herbal medicine, which has been used to tonify the kidney and strengthen yang for a long time in China. In this study, the effects of M. officinalis Polysaccharide (MOP) on experimental varicocele adolescent rats were investigated. The result showed that varicocele destroyed the structure of the seminiferous epithelium and decreased the TJ protein expression (Occludin, Claudin-11, and ZO-1), testosterone (T) concentration in the left testicular tissue and serum, and serum levels of inhibin B (INHB), while increasing the levels of cytokines (TGF-3 and TNF-) in the left testicular tissue, as well as serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and antisperm antibody (AsAb). MOP repaired the damaged seminiferous epithelium and TJ and reduced the levels of cytokines (TGF-3 and TNF-) as well as serum levels of GnRH, FSH, LH, and AsAb, while upregulating TJ protein expression, T level in the left testicular tissue and serum, and serum INHB levels. In summary, we conclude that MOP promotes spermatogenesis and counteracts the varicocele-induced damage to the seminiferous epithelium and TJ, probably via decreasing cytokines (TGF-3 and TNF-) levels and regulating the abnormal sex hormones levels in experimental varicocele rats.