Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 5365291, 11 pages
http://dx.doi.org/10.1155/2016/5365291
Research Article

Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats

1Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China
2Research Center for Neurobiology, School of Basic Medical Sciences, Fujian Medical University, No. 1 Xueyuan Road, Minhou County, Fuzhou, Fujian 350108, China

Received 24 May 2016; Accepted 14 November 2016

Academic Editor: Ho Lin

Copyright © 2016 Lihong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I.-T. Kim, H.-J. Park, J.-H. Nam et al., “In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis,” The Journal of Pharmacy and Pharmacology, vol. 57, no. 5, pp. 607–615, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. H. Guo, H. M. Wang, T. Huang, N. Li, and Z. C. Lin, “Determination of polysaccharide from Morinda officinalis How in Nanjing,” Journal of Fujian College of TCM, vol. 16, pp. 32–33, 2006. View at Google Scholar
  3. Z. Cheng, H. Z. Deng, Q. L. Mo, and Z. W. Li, “Determination of the contents of valuable compositions of Morinda officinalis how in different regions and analysis of its protection for the liver,” Journal of Hainan Normal University, vol. 16, pp. 64–67, 2004. View at Google Scholar
  4. F.-J. Wang, W. Wang, R. Li, B. Song, Y.-H. Zhang, and Y.-X. Zhou, “[Morinda officialis how extract improves microwave-induced reproductive impairment in male rats],” Zhonghua Nan Ke Xue, vol. 19, no. 4, pp. 340–345, 2013. View at Google Scholar · View at Scopus
  5. B. Song, F. Wang, and W. Wang, “Effect of aqueous extract from Morinda officinalis F. C. how on microwave-induced hypothalamic-pituitary-testis axis impairment in male Sprague-Dawley rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 360730, 10 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. C. L. Sears, “Molecular physiology and pathophysiology of tight junctions. V. Assault of the tight junction by enteric pathogens,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 279, no. 6, pp. G1129–G1134, 2000. View at Google Scholar · View at Scopus
  7. C. Y. Cheng and D. D. Mruk, “Cell junction dynamics in the testis: sertoli-germ cell interactions and male contraceptive development,” Physiological Reviews, vol. 82, no. 4, pp. 825–874, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. D. D. Mruk and C. Y. Cheng, “Tight junctions in the testis: new perspectives,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 365, no. 1546, pp. 1621–1635, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Janecki, A. Jakubowiak, and A. Steinberger, “Effect of cadmium chloride on transepithelial electrical resistance of sertoli cell monolayers in two-compartment cultures—a new model for toxicological investigations of the ‘blood-testis’ barrier in vitro,” Toxicology and Applied Pharmacology, vol. 112, no. 1, pp. 51–57, 1992. View at Publisher · View at Google Scholar · View at Scopus
  10. N. P. Y. Chung and C. Y. Cheng, “Is cadmium chloride-induced inter-sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis?” Endocrinology, vol. 142, no. 5, pp. 1878–1888, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Hellani, J. Ji, C. Mauduit, C. Deschildre, E. Tabone, and M. Benahmed, “Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis,” Endocrinology, vol. 141, no. 8, pp. 3012–3019, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. M. J. McCabe, G. A. Tarulli, S. J. Meachem, D. M. Robertson, P. M. Smooker, and P. G. Stanton, “Gonadotropins regulate rat testicular tight junctions in vivo,” Endocrinology, vol. 151, no. 6, pp. 2911–2922, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. W.-Y. Lui, W. M. Lee, and C. Y. Cheng, “Transforming growth factor β3 regulates the dynamics of sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway,” Biology of Reproduction, vol. 68, no. 5, pp. 1597–1612, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. W.-Y. Lui, C.-H. Wong, D. D. Mruk, and C. Y. Cheng, “TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An In Vivo Study,” Endocrinology, vol. 144, no. 4, pp. 1139–1142, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. C.-H. Wong, D. D. Mruk, W.-Y. Lui, and C. Y. Cheng, “Regulation of blood-testis barrier dynamics: an in vivo study,” Journal of Cell Science, vol. 117, no. 5, pp. 783–798, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Xia and C. Y. Cheng, “TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An In Vivo Study,” Developmental Biology, vol. 280, no. 2, pp. 321–343, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. C. V. Pérez, C. M. Sobarzo, P. V. Jacobo et al., “Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions,” Biology of Reproduction, vol. 87, no. 5, article 122, 2012. View at Google Scholar · View at Scopus
  18. W.-Y. Lui, W. M. Lee, and C. Y. Cheng, “Transforming growth factor-β3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11,” Endocrinology, vol. 142, no. 5, pp. 1865–1877, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. W. S. Choi and S. W. Kim, “Current issues in varicocele management: a review,” The World Journal of Men's Health, vol. 31, no. 1, pp. 12–20, 2013. View at Publisher · View at Google Scholar
  20. N. E. Ahlberg, O. Bartley, and N. Chidekel, “Right and left gonadal veins. An anatomical and statistical study,” Acta Radiologica: Diagnosis, vol. 4, no. 6, pp. 593–601, 1966. View at Publisher · View at Google Scholar · View at Scopus
  21. P. V. Bach, B. B. Najari, and M. Goldstein, “Varicocele—a case for early intervention,” F1000Research, vol. 5, p. 1792, 2016. View at Publisher · View at Google Scholar
  22. T. T. Turner, “Varicocele: still an enigma,” Journal of Urology, vol. 129, no. 4, pp. 695–699, 1983. View at Google Scholar · View at Scopus
  23. J. P. Jarow, “Effects of varicocele on male fertility,” Human Reproduction Update, vol. 7, no. 1, pp. 59–64, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Mehta and M. Goldstein, “Microsurgical varicocelectomy: a review,” Asian Journal of Andrology, vol. 15, no. 1, pp. 56–60, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Khera and L. I. Lipshultz, “Evolving approach to the varicocele,” Urologic Clinics of North America, vol. 35, no. 2, pp. 183–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. P. C. Fretz and J. I. Sandlow, “Varicocele: current concepts in pathophysiology, diagnosis, and treatment,” Urologic Clinics of North America, vol. 29, no. 4, pp. 921–937, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Uzbek, M. Yurekli, A. Soylu, M. Davarci, and M. D. Balbay, “The role of adrenomedullin in varicocele and impotence,” BJU International, vol. 86, no. 6, pp. 694–698, 2000. View at Google Scholar · View at Scopus
  28. D. F. Cameron, F. E. Snydle, M. H. Ross, and D. M. Drylie, “Ultrastructural alterations in the adluminal testicular compartment in men with varicocele,” Fertility and Sterility, vol. 33, no. 5, pp. 526–533, 1980. View at Publisher · View at Google Scholar · View at Scopus
  29. F. E. Snydle and D. F. Cameron, “Surgical induction of varicocele in the rabbit,” Journal of Urology, vol. 130, no. 5, pp. 1005–1009, 1983. View at Google Scholar · View at Scopus
  30. T. Lu, L. J. Zhang, and S. R. Li, “An ultrastructural study on germinal epithelium of experimental varicoele,” Chinese Journal of Physical Medicine, vol. 4, pp. 232–235, 1994. View at Google Scholar
  31. B. R. Gilbert, S. S. Witkin, and M. Goldstein, “Correlation of sperm-bound immunoglobulins with impaired semen analysis in infertile men with varicoceles,” Fertility and Sterility, vol. 52, no. 3, pp. 469–473, 1989. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Rajfer, T. T. Turner, F. Rivera, S. S. Howards, and S. C. Sikka, “Inhibition of testicular testosterone biosynthesis following experimental varicocele in rats,” Biology of Reproduction, vol. 36, no. 4, pp. 933–937, 1987. View at Publisher · View at Google Scholar · View at Scopus
  33. R. W. Hudson, V. A. Crawford, and D. E. McKay, “The gonadotropin response of men with varicoceles to a four-hour infusion of gonadotropin-releasing hormone,” Fertility and Sterility, vol. 36, no. 5, pp. 633–637, 1981. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Guarino, B. Tadini, and M. Bianchi, “The adolescent varicocele: the crucial role of hormonal tests in selecting patients with testicular dysfunction,” Journal of Pediatric Surgery, vol. 38, no. 1, pp. 120–123, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Sofikitis, C. Takahashi, H. Kadowaki et al., “Surgical repair versus medical treatment of varicocele in the rat: pharmacological manipulation of the varicocelized testicle,” European Urology, vol. 22, no. 1, pp. 44–52, 1992. View at Google Scholar · View at Scopus
  36. S. R. Plymate, C. A. Paulsen, and R. I. McLachlan, “Relationship of serum inhibin levels to serum follicle stimulating hormone and sperm production in normal men and men with varicoceles,” Journal of Clinical Endocrinology and Metabolism, vol. 74, no. 4, pp. 859–864, 1992. View at Publisher · View at Google Scholar · View at Scopus
  37. T. T. Turner, “The study of varicocele through the use of animal models,” Human Reproduction Update, vol. 7, no. 1, pp. 78–84, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Dong, Q. Zhang, Y. Li et al., “Extraction, characterization and antioxidant activities of polysaccharides of Chuanminshen violaceum,” International Journal of Biological Macromolecules, vol. 86, pp. 224–232, 2016. View at Publisher · View at Google Scholar
  39. E. Guneli, K. Tugyan, H. Ozturk, M. Gumustekin, S. Cilaker, and N. Uysal, “Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats,” European Surgical Research, vol. 40, no. 4, pp. 354–360, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Najafi, F. Farokhi, A. Shalizar Jalali, and Z. Akbarizadeh, “Protection against cyclosporine-induced reprotoxicity by satureja khuzestanica essential oil in male rats,” Int J Fertil Steril, vol. 9, no. 4, pp. 548–557, 2016. View at Google Scholar
  41. Y. Yin, K. L. Hawkins, W. C. Dewolf, and A. Morgentaler, “Heat stress causes testicular germ cell apoptosis in adult mice,” Journal of Andrology, vol. 18, no. 2, pp. 159–165, 1997. View at Google Scholar · View at Scopus
  42. E. C. Jensen, “The Basics of Western Blotting,” Anatomical Record, vol. 295, no. 3, pp. 369–371, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. R.-L. Dun, M. Yao, L. Yang et al., “Traditional Chinese herb combined with surgery versus surgery for varicocele infertility: a systematic review and meta-analysis,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 689056, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. H. G. Tempest, S. T. Homa, E. J. Routledge, A. Garner, X.-P. Zhai, and D. K. Griffin, “Plants used in Chinese medicine for the treatment of male infertility possess antioxidant and anti-oestrogenic activity,” Systems Biology in Reproductive Medicine, vol. 54, no. 4-5, pp. 185–195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. A. S. Fanning, L. L. Mitic, and J. M. Anderson, “Transmembrane proteins in the tight junction barrier,” Journal of the American Society of Nephrology, vol. 10, no. 6, pp. 1337–1345, 1999. View at Google Scholar · View at Scopus
  46. B. R. Stevenson, J. D. Siliciano, M. S. Mooseker, and D. A. Goodenough, “Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia,” The Journal of Cell Biology, vol. 103, no. 3, pp. 755–766, 1986. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Fiorini, A. Tilloy-Ellul, S. Chevalier, C. Charuel, and G. Pointis, “Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants,” Reproductive Toxicology, vol. 18, no. 3, pp. 413–421, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. M. W. M. Li, W. Xia, D. D. Mruk et al., “Tumor necrosis factor α reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes,” Journal of Endocrinology, vol. 190, no. 2, pp. 313–329, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. Y. Han, J. Wu, T. Liu et al., “Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida,” International Journal of Biological Macromolecules, vol. 83, pp. 42–49, 2016. View at Publisher · View at Google Scholar · View at Scopus
  50. S. R. Fahmy, A. I. Amien, F. M. Abd-Elgleel, and S. M. Elaskalany, “Antihepatotoxic efficacy of Mangifera indica L. polysaccharides against cyclophosphamide in rats,” Chemico-Biological Interactions, vol. 244, pp. 113–120, 2016. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Wangensteen, D. Diallo, and B. S. Paulsen, “Medicinal plants from Mali: chemistry and biology,” Journal of Ethnopharmacology, vol. 176, pp. 429–437, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. J. L. Evers, J. A. Collins, and P. Vandekerckhove, “Surgery or embolisation for varicocele in subfertile men,” Cochrane Database of Systematic Reviews, no. 1, Article ID Cd000479, 2001. View at Google Scholar