Effects of Jia-Wei-Xiao-Yao-San on the Peripheral and Lymphatic Pharmacokinetics of Paclitaxel in Rats

Table 3

Pharmacokinetic parameters of paclitaxel (5 mg/kg, i.v. infusion) with or without JWXYS (1.23 g/kg, p.o. for 7 days) pretreatment.

PK parameters	Paclitaxel (5 mg/kg, i.v. infusion)	Paclitaxel (5 mg/kg, i.v. infusion) + JWXYS (1.23 g/kg, p.o. × 7)
Plasma
(ng/mL)	2355 ± 314	1630 ± 141
(min µg/mL)	315 ± 38.2	209 ± 18.9
(min)	73.7 ± 12.2	111 ± 12.8
Vd (L/kg)	1.39 ± 0.15	2.00 ± 0.17
CL (mL/min/kg)	17.5 ± 1.95	25.1 ± 2.55
MRT (min)	68.6 ± 3.70	62.9 ± 1.71
Lymph
(ng/mL)	648 ± 94.3	494 ± 58.7
(min µg/mL)	113 ± 12.7	89.8 ± 8.25
(min)	116 ± 17.6	122 ± 7.0
Vd (L/kg)	8.08 ± 1.59	10.0 ± 1.09
CL (mL/min/kg)	45.7 ± 8.17	48.3 ± 4.36
MRT (min)	119 ± 4.77	130 ± 4.34
Biodistribution (%)	39 ± 5	45 ± 4
Lymph absorption rate (%)	27 ± 3	30 ± 2

Data expressed as mean ± SEM (). : the peak plasma concentration of a drug after administration; AUC: area under the concentration versus time curve; : elimination half-life; Vd: volume of distribution; CL: total body clearance; MRT: mean residence time; biodistribution, (/) × 100: the distribution of paclitaxel from plasma to lymph; lymph absorption rate, [(/) × 100]: the lymph absorption rate of paclitaxel. Significantly different from paclitaxel alone at .