Research Article

The Rhizome Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates Mesalazine-Resistant Colitis in Mice

Figure 4

Effects of DWac and mesalazine on the expression of M1 and M2 macrophage markers in mice with MRC. Mesalazine-resistant colitis (MRC) was induced by the repeated intrarectal injection of TNBS and oral administration of mesalazine. MRC mice, except normal control group, were orally treated with saline (TM) or test agents (TM+M, 30 mg/kg mesalazine; TM+DM, the mixture of 15 mg/kg DWac and 15 mg/kg mesalazine; TM+D, 30 mg/kg DWac) for 3 days after TNBS treatment. TN was treated 4 times with TNBS alone and vehicle. The mice were killed 18 h after the final administration of test agents. M1 and M2 macrophage markers were assayed by qPCR. All data are mean ± SD (). versus control group. versus TM group.
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