Table 5: Compositions of herbal medicines and adverse events in the included RCTs.

Intervention Study IDCompositionsFormulationAdverse events

Dia-NoAgrawal et al., 2008 [13]Syzygium cumini 20%, Gymnema sylvestre 20%,
Trigonella foenumgraecum 14%, Emblica officinalis 10%, Azadirachta indica 7%, Cassia auriculata 7%, Tribulus terrestris 7%, Andrographis paniculata 5%, Pterocarpus marsupium 5%, and Momordica charantia 5%
TabletNausea 2, vomiting 1, loss of appetite 2, and burning epigastrium 1 in intervention group

Yiqi Huaju RecipeChen et al., 2014 [14]Astragalus membranaceus, Coptis chinensis, Typha orientalis, Alisma canaliculatum, Artemisia capillaris, and so forthDecoctionSkin hypersensitivity 2 in intervention group

Daotan decoctionZhang et al., 2014 [15]Pinellia ternata 10 g, Arisaema erubescens Schott 5 g, Citrus reticulata 10 g, Citrus sinensis 10 g, Poria cocos 15 g,
Zingiber officinale 5 g, and Glycyrrhiza uralensis 5 g
DecoctionNot reported

Gegen Shanzha decoctionXu et al., 2014 [16]Pueraria montana and Crataegus pinnatifida Bunge each 10~20 g (1 : 1)DecoctionNot reported

Xuefu Zhuyu decoctionLi, 2014 [17]Prunus persica (L.) Batsch 9 g Carthamus tinctorius 9 g, Rehmannia glutinosa 9 g, Ligusticum officinale Kitag. 5 g, Angelica sinensis 9 g,
Paeonia lactiflora Pallas 6 g, Achyranthes japonica Nakai 9 g, Platycodon grandiflorum 5 g, Bupleurum falcatum 3 g,
Citrus aurantium L. 6 g, and Glycyrrhiza uralensis 3 g
DecoctionNot reported

Qinggan Jiangtang tabletWang et al., 2005 [18]Bupleurum falcatum 8 g, Gardenia jasminoides 10 g, Coptis chinensis 4 g, Scutellaria baicalensis 8 g, Rehmannia glutinosa 15 g,
Lilium longiflorum 20 g, Anemarrhena asphodeloides Bunge 10 g,
pollen 20 g, Gastrodia elata Blume 10 g, and Cassia occidentalis L. 20 g
TabletNot reported

Modified Banxia Baizhu Tianma decoctionLiu et al., 2008 [19]Pinellia ternata 9 g, Gastrodia elata Blume 6 g, Pueraria montana 20 g,
Atractylodes macrocephala Koidzumi 15 g, Alisma canaliculatum 30 g,
Pleuropterus multlforus 15 g, Crataegus pinnatifida Bunge 15 g,
Salviae miltiorrhizae Radix 25 g, Astragalus membranaceus 30 g,
Poria cocos 15 g, Cassia obtusifolia L. 15 g, and Citrus reticulata 10 g,
DecoctionNot reported

Pinggan Jiangya pillZhang et al., 2010 [20]Prunella vulgaris 24 g, Uncaria rhynchophylla 20 g, Saiga tataria L. 2 g, Folium ilicis (Kuding tea) 10 g,
Sophora japonica L. 10 g, Pteria martensii 30 g,
Tribulus terrestris L. 20 g, magnetitum 20 g, Scutellaria baicalensis 15 g, Cassia obtusifolia L. 20 g, Achyranthes japonica Nakai 15 g
PillFacial flush 4 in control group

Huanglian Wendan decoctionGuan et al., 2012 [21]Coptis chinensis, Pinellia ternata, Citrus reticulata, Poria cocos, Pueraria montana, Cassia obtusifolia L., Astragalus membranaceus, Phyllostachys bambusoides Sieb. et Zucc., Salviae miltiorrhizae Radix, and Glycyrrhiza uralensisDecoctionGastrointestinal disorder 1 in intervention group, abdominal pain and vomiting 4, and weakness 1 in control group

Xueguan Ruanhua decoctionDong, 2012 [22]Taxillus chinensis, Apocynum cannabinum, Angelica sinensis, Paeonia lactiflora Pallas, Ligusticum officinale Kitag.,
Gastrodia elata Blume, Eucommia ulmoides Oliver,
Salviae miltiorrhizae Radix, Vitex rotundifolia L.,
Chrysanthemum morifolium, Hirudo nipponica Whitman, mulberry leaf, Coptis chinensis, Pueraria montana, Fritillaria cirrhosa D. Don, and so forth
DecoctionNausea and vomiting 2, hypoglycemia 1, and hypotension 3 in control group

Shengjiangtongmai powderCui and Wie, 2014 [23]Bombyx mori 10 g, Cryptotympana coreana 10 g, Curcuma longa 9 g, Rheum palmatum 12 g, Coptis chinensis 6 g,
Panax quinquefolius 25 g, Atractylodes japonica 15 g,
Pinellia ternata 12 g, Trichosanthes kirilowii Maxim.15 g
DecoctionNot reported

Shenling Jianpihuashi decoctionDanyang Zhao and Danun Zhao, 2015 [24]Codonopsis tangshen Oliver 15 g, Astragalus membranaceus 15 g,
Poria cocos 15 g, Atractylodes macrocephala Koidzumi 15 g, Dioscorea opposita 15 g, Coixlachrymajobi var. mayuen 15 g, Amomum xanthioides 6 g, Nelumbo nucifera 10 g, Alisma canaliculatum 15 g, and Panax notoginseng 3 g
DecoctionGastrointestinal disorder 2 in control group