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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 5970367, 23 pages
Review Article

A Systematic Review on the Effects of Botanicals on Skeletal Muscle Health in Order to Prevent Sarcopenia

1Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutrition, Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona, University of Pavia, 27100 Pavia, Italy
2Department of Clinical Sciences, Faculty of Medicine and Surgery, University of Milan, Milan, Italy
3Azienda di Servizi alla Persona, Pavia, Italy
4Research and Development Unit, Indena, 20139 Milan, Italy
5Department of Brain and Behavioral Sciences, Medical and Genomic Statistics Unit, University of Pavia, 27100 Pavia, Italy
6Department of Public Health, Experimental and Forensic Medicine, Biostatistics and Clinical Epidemiology Unit, University of Pavia, 27100 Pavia, Italy

Received 13 November 2015; Revised 20 January 2016; Accepted 24 January 2016

Academic Editor: Hyunsu Bae

Copyright © 2016 M. Rondanelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We performed a systematic review to evaluate the evidence-based medicine regarding the main botanical extracts and their nutraceutical compounds correlated to skeletal muscle health in order to identify novel strategies that effectively attenuate skeletal muscle loss and enhance muscle function and to improve the quality of life of older subjects. This review contains all eligible studies from 2010 to 2015 and included 57 publications. We focused our attention on effects of botanical extracts on growth and health of muscle and divided these effects into five categories: anti-inflammation, muscle damage prevention, antifatigue, muscle atrophy prevention, and muscle regeneration and differentiation.