Application of Traditional Chinese Medical Herbs in Prevention and Treatment of Respiratory Syncytial Virus

Table 3

Aqueous extracts of TCMHs inhibiting RSV.

Herbs	Used part	Anti-RSV activity			References
		IC50 (μg/mL)	CC50 (μg/mL)	SI
Bupleurum chinense	Root	36.8	441.3	12.0	[44]
Gardenia jasminoides		21.0	112.1	5.3
Isatis indigotica		50.0	1000	20.0
Ipomoea cairica		52.1	833.3	16.0
Polygonum multiflorum		52.1	>1000.0	>19.2
Platycodon grandiflorum		<44.1	352.5	>8.0
Polygonum cuspidatum Sieb.		<13.0	>200.0	>15.4
Scutellaria baicalensis		<10.4	>62.5	6.0
Sophora flavescens		52.1	833.3	16.0
Tinospora capillipes		17.2	275.8	16.0
Paeonia suffruticosa	Root cortex	26.0	>833.3	>32.0
Phragmites communis	Rhizome	46.5	185.8	4.0
Andrographis paniculata	Aerial parts	27.6	295.0	10.7
Artemisia capillaries		13.0	208.3	16.0
Schizonepeta tenuifolia		49.2	196.9	>4.0
Scutellaria indica		31.3	350.0	11.2
Perilla frutescens	Leaf	37.6	255.6	6.0
Lonicera japonica	Flower bud	50.0	>1000.0	>20.0
Dendranthema morifolium	Flower	50.5	269.2	5.3
Forsythia suspense	Fruit	50.0	1000.0	20.0
Prunella vulgaris L.	Fruit spike	<10.4	>62.5	6.0
Callicarpa nudiflora	Whole plant	37.5	800.0	21.3
Patrinia villosa		<13.0	416.7	>32.0
Sarcandra glabra		50.0	1000.0	20.0
Selaginella sinensis		50.0	>62.5	>20.0
Blumea laciniata Callicarpa		15.6	243.8	15.5	[49]
Laggera pterodonta		15.6	500.0	31.8
Mussaenda pubescens		512.5	32.0	16.0
Schefflera octophylla	Leaf stalk	12.5	500.0	40.0
Ribavirin [44]	—	2.6	62.5	24.0	[44]
Ribavirin [49]	—	3.0	62.5	20.8	[49]

IC50 is the concentration of the sample required to inhibit virus-induced CPE 50%; CC50 is the concentration of the 50% cytotoxic effect; selective index (SI) or therapeutic index (TI): CC50/IC50.