Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

Figure 4

XFHM suppressed the differentiation of CD4⁺IFNγ⁺ Th1 cells and the production of IFNγ and T-bet. (a) and (b) The percentage of CD4⁺IFNγ⁺ Th1 cells in spleens isolated from mice treated for 4 weeks. (c) The IFNγ levels in sera of mice detected by ELISA. The results are presented in the bar chart. (d) T-bet was detected in whole spleen tissue lysates by western blot analysis. The results are presented in the bar chart. GAPDH was used as an internal control. Data are presented as means ± SD. , compared to the normal group; , compared to the model group.

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