Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

Figure 6

XFHM inhibited CD4⁺IL-17⁺ Th17 cells differentiation and the production of IL-17, STAT3, and RORγ. (a) and (b) The percentage of CD4⁺IL-17⁺ Th17 cells in spleen isolated from mice treated for 4 weeks. (c) The levels of IL-17 in sera of mice detected by ELISA. The results are presented in the bar chart. (d) STAT3 and RORγ were detected in whole spleen tissue lysates by western blot analysis. GAPDH was used as an internal control. Data were presented as means ± SD. compared to the normal group; compared to the model group.

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