Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 6356871, 14 pages
http://dx.doi.org/10.1155/2016/6356871
Research Article

Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

1Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
2School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, China
3Department of Rheumatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

Received 5 May 2016; Revised 17 July 2016; Accepted 26 July 2016

Academic Editor: Young-Su Yi

Copyright © 2016 Bo Nie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Andreas, C. Lübke, T. Häupl et al., “Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study,” Arthritis Research & Therapy, vol. 10, no. 1, p. R9, 2008. View at Publisher · View at Google Scholar
  2. U. Müller-Ladner, T. Pap, R. E. Gay, M. Neidhart, and S. Gay, “Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis,” Nature Clinical Practice Rheumatology, vol. 1, no. 2, pp. 102–110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. I. B. McInnes and G. Schett, “The pathogenesis of rheumatoid arthritis,” The New England Journal of Medicine, vol. 365, no. 23, pp. 2205–2219, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. You, S.-A. Yoo, S. Choi et al., “Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 1, pp. 550–555, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Bartok and G. S. Firestein, “Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis,” Immunological Reviews, vol. 233, no. 1, pp. 233–255, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Kobezda, S. Ghassemi-Nejad, K. Mikecz, T. T. Glant, and Z. Szekanecz, “Of mice and men: how animal models advance our understanding of T-cell function in RA,” Nature Reviews Rheumatology, vol. 10, no. 3, pp. 160–170, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. E. J. Wehrens, B. J. Prakken, and F. Van Wijk, “T cells out of control-impaired immune regulation in the inflamed joint,” Nature Reviews Rheumatology, vol. 9, no. 1, pp. 34–42, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Laurence and J. J. O'Shea, “TH-17 differentiation: of mice and men,” Nature Immunology, vol. 8, no. 9, pp. 903–905, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. W. B. van den Berg and P. Miossec, “IL-17 as a future therapeutic target for rheumatoid arthritis,” Nature Reviews Rheumatology, vol. 5, no. 10, pp. 549–553, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Nakae, A. Nambu, K. Sudo, and Y. Iwakura, “Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice,” The Journal of Immunology, vol. 171, no. 11, pp. 6173–6177, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. M. E. Morgan, R. Flierman, L. M. van Duivenvoorde et al., “Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells,” Arthritis & Rheumatism, vol. 52, no. 7, pp. 2212–2221, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Liu, H. Cao, Y. Ji et al., “Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes,” Scientific Reports, vol. 5, Article ID 13982, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. N.-H. Yim, A. Kim, Y. P. Jung, T. Kim, C. J. Ma, and J. Y. Ma, “Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article 336, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. J.-F. Zeng, M.-Z. Li, M. Li, B.-Q. Sun, W.-H. Zhou, and F. Yang, “Xianfang huoming decoction jiawei iontophoresis analysis combined with clinical of arthroscopic debridement for osteoarthritis of kneei,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 20, no. 11, pp. 199–202, 2014. View at Google Scholar
  15. D. X. Gao Xuan, Z. Yu, and Z. Wanliang, “Clinical observation on the treatment of hip joint synovitis in children with internal and external application of Xianfang Huoming Yin,” Rheumatism and Arthritis, vol. 4, no. 4, p. 3, 2015. View at Google Scholar
  16. C. L. Tang Nong, Z. Lijun, L. Guobiao, and H. Xiaoqi, “Influences of Lijie Capsules on expressions of Fas and FasL genes in lymphocytes in rats with adjuvant arthritis,” Journal of Beijing University of Traditional Chinese Medicine, vol. 29, no. 7, p. 4, 2016. View at Google Scholar
  17. G. Murdaca, F. Spanò, and F. Puppo, “Use of leflunomide plus TNF-α inhibitors in rheumatoid arthritis,” Expert Opinion on Drug Safety, vol. 12, no. 6, pp. 801–804, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-B. Hsiao, C.-C. Hsieh, J.-B. Wu, H. Lin, and W.-C. Lin, “Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, article 80, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Chen, S. Xiao, Z. Li, N. Ai, and X. Fan, “Chemical and metabolic profiling of Si-Ni decoction analogous formulae by high performance liquid chromatography-mass spectrometry,” Scientific Reports, vol. 5, Article ID 11638, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Wang, P. Chen, Y. Xu, X. Li, and X. Fan, “Characterization of the chemical constituents in Da-Huang-Gan-Cao-Tang by liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and liquid chromatography coupled with ion trap mass spectrometry,” Journal of Separation Science, vol. 37, no. 14, pp. 1748–1761, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Yan, C.-Z. Chai, D.-W. Wang, X.-Y. Yue, D.-N. Zhu, and B.-Y. Yu, “HPLC-DAD-Q-TOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction,” Journal of Pharmaceutical and Biomedical Analysis, vol. 80, pp. 192–202, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Takahi, J. Hashimoto, K. Hayashida et al., “Early closure of growth plate causes poor growth of long bones in collagen-induced arthritis rats,” Journal of Musculoskeletal Neuronal Interactions, vol. 2, no. 4, pp. 344–351, 2002. View at Google Scholar · View at Scopus
  23. C. A. Singer, “T-bet is induced by interferon-γ to mediate chemokine secretion and migration in human airway smooth muscle cells,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 300, no. 4, pp. L633–L641, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Zhu, H. Yamane, J. Cote-Sierra, L. Guo, and W. E. Paul, “GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors,” Cell Research, vol. 16, no. 1, pp. 3–10, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. Q. Ruan, V. Kameswaran, Y. Zhang et al., “The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis,” The Journal of Experimental Medicine, vol. 208, no. 11, pp. 2321–2333, 2011. View at Publisher · View at Google Scholar
  26. T. J. Harris, J. F. Grosso, H. R. Yen et al., “Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity,” The Journal of Immunology, vol. 179, no. 7, pp. 4313–4317, 2007. View at Publisher · View at Google Scholar
  27. T. W. Corson and C. M. Crews, “Molecular understanding and modern application of traditional medicines: triumphs and trials,” Cell, vol. 130, no. 5, pp. 769–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Xue and R. Roy, “Studying traditional Chinese medicine,” Science, vol. 300, no. 5620, pp. 740–741, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. W.-S. Choi, P.-G. Shin, J.-H. Lee, and G.-D. Kim, “The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells,” Cellular Immunology, vol. 280, no. 2, pp. 164–170, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Wei, H. Chi, H. Kodama, and G. Chen, “Anti-inflammatory effect of three iridoids in human neutrophils,” Natural Product Research, vol. 27, no. 10, pp. 911–915, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Ni, D. Yang, L. Song, and C. Li, “Protective effects of paeoniflorin on alveolar bone resorption and soft-tissue breakdown in experimental periodontitis,” Journal of Periodontal Research, vol. 51, no. 2, pp. 257–264, 2016. View at Publisher · View at Google Scholar
  32. N. Yamabe, J. S. Noh, C. H. Park et al., “Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice,” European Journal of Pharmacology, vol. 648, no. 1–3, pp. 179–187, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Mencherini, A. Cau, G. Bianco, R. Della Loggia, R. P. Aquino, and G. Autore, “An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties,” Journal of Pharmacy and Pharmacology, vol. 59, no. 6, pp. 891–897, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Zhao, J. Ye, G.-T. Wu, X.-J. Peng, P.-F. Xia, and Y. Ren, “Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte,” Journal of Ethnopharmacology, vol. 172, pp. 100–107, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. W.-J. Zhang and B. Frei, “Astragaloside IV inhibits NF-κB activation and inflammatory gene expression in LPS-treated mice,” Mediators of Inflammation, vol. 2015, Article ID 274314, 11 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Jing, M. Chunhua, and W. Shumin, “Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro,” Toxicology and Applied Pharmacology, vol. 285, no. 2, pp. 128–135, 2015. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Chen, Q. Wu, G. Chi et al., “Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice,” International Immunopharmacology, vol. 16, no. 2, pp. 139–147, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Moon, Y. M. Ha, H. J. Jang et al., “Isoimperatorin, cimiside e and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 336–344, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Lou, Y. Liu, J. Zhou et al., “Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1β-induced fibroblast-like synoviocytes through regulating the activation of NF-κB and JAK/STAT-signaling pathways,” Immunopharmacology and Immunotoxicology, vol. 37, no. 6, pp. 499–507, 2015. View at Publisher · View at Google Scholar · View at Scopus
  40. M. M. Mia and R. A. Bank, “The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis,” Cell and Tissue Research, vol. 363, no. 3, pp. 775–789, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. J. S. Park, H. J. Lee, D. Y. Lee et al., “Chondroprotective effects of wogonin in experimental models of osteoarthritis in vitro and in vivo,” Biomolecules and Therapeutics, vol. 23, no. 5, pp. 442–448, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Chen, N. Lu, Y. Ling et al., “Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction,” Toxicology, vol. 259, no. 1-2, pp. 10–17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. Y.-R. Li, D.-Y. Chen, C.-L. Chu et al., “Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis,” Journal of Nutritional Biochemistry, vol. 26, no. 12, pp. 1467–1478, 2016. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Park, S. H. Kim, D. Cho, and T. S. Kim, “Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity,” Immunology, vol. 116, no. 1, pp. 71–81, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. M. De Carli, M. M. D'Elios, G. Zancuoghi, S. Romagnani, and G. Del Prete, “Review human Th1 and Th2 cells: functional properties, regulation of development and role in autoimmunity,” Autoimmunity, vol. 18, no. 4, pp. 301–308, 1994. View at Publisher · View at Google Scholar · View at Scopus
  46. O. Snir, J. Bäcklund, J. Boström et al., “Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 64, no. 8, pp. 2482–2488, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Von Delwig, J. Locke, J. H. Robinson, and W.-F. Ng, “Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis,” Arthritis and Rheumatism, vol. 62, no. 1, pp. 143–149, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. X. Yuan, B. Tong, Y. Dou, X. Wu, Z. Wei, and Y. Dai, “Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Th17 and Treg cells via the aryl hydrocarbon receptor,” Biochemical Pharmacology, vol. 101, pp. 87–99, 2016. View at Publisher · View at Google Scholar · View at Scopus
  49. M. L. Kapsenberg, “Dendritic-cell control of pathogen-driven T-cell polarization,” Nature Reviews Immunology, vol. 3, no. 12, pp. 984–993, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. A. K. Abbas, K. M. Murphy, and A. Sher, “Functional diversity of helper T lymphocytes,” Nature, vol. 383, no. 6603, pp. 787–793, 1996. View at Publisher · View at Google Scholar · View at Scopus
  51. D. Amsen, C. G. Spilianakis, and R. A. Flavell, “How are TH1 and TH2 effector cells made?” Current Opinion in Immunology, vol. 21, no. 2, pp. 153–160, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. I. M. Djuretic, D. Levanon, V. Negreanu et al., “Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells,” Nature Immunology, vol. 8, no. 2, pp. 145–153, 2007. View at Google Scholar
  53. K. M. Ansel, I. Djuretic, B. Tanasa, and A. Rao, “Regulation of Th2 differentiation and Il4 locus accessibility,” Annual Review of Immunology, vol. 24, pp. 607–656, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Amsen, J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell, “Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells,” Cell, vol. 117, no. 4, pp. 515–526, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. H. H. Hofstetter, S. M. Ibrahim, D. Koczan et al., “Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis,” Cellular Immunology, vol. 237, no. 2, pp. 123–130, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. E. Bettelli, T. Korn, and V. K. Kuchroo, “Th17: the third member of the effector T cell trilogy,” Current Opinion in Immunology, vol. 19, no. 6, pp. 652–657, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. F. C. Breedveld and J.-M. Dayer, “Leflunomide: mode of action in the treatment of rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 59, no. 11, pp. 841–849, 2000. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Zeyda, M. Poglitsch, R. Geyeregger et al., “Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation,” Arthritis and Rheumatism, vol. 52, no. 9, pp. 2730–2739, 2005. View at Publisher · View at Google Scholar · View at Scopus
  59. S. E. Bilasy, S. S. Essawy, M. F. Mandour, E. A. I. Ali, and S. A. Zaitone, “Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis,” Pharmacological Reports, vol. 67, no. 1, pp. 102–114, 2015. View at Publisher · View at Google Scholar · View at Scopus