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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 6435040, 7 pages
http://dx.doi.org/10.1155/2016/6435040
Research Article

Effects of Yishen Pinggan Recipe on Renal Protection and NF-κB Signaling Pathway in Spontaneously Hypertensive Rats

1Department of Traditional Chinese Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
2Emergency Department, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
3Central Laboratory and Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China

Received 2 November 2015; Revised 5 February 2016; Accepted 11 February 2016

Academic Editor: Elia Ranzato

Copyright © 2016 Guodong Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammation is an important etiological factor of hypertensive renal damage. The effects of Yishen Pinggan Recipe (YPR) on urine microalbumin, histology, and NF-κB/P65, IκB-α, IL-1β, IL-6, and TNF-α in renal tissues were evaluated in SHR to explore the mechanism of its renal protection in hypertensive renal damage. The SBP of 12-week-old SHR was  mmHg and DBP was  mmHg. Without treatment, the 24-week-old SHRs’ SBP was  mmHg and DBP was  mmHg. After the 12-week-old SHR were administered YPR for 12 weeks, the rats’ SBP was  mmHg and DBP was  mmHg; YPR could lower blood pressure in SHR. And renal function damage was observed in 24-week-old SHR without treatment, manifested as urine protein and morphological changes which could be inhibited by YPR. In addition, YPR could reduce the expression of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in kidneys. It could also inhibit the nuclear translocation of NF-κB p65 and degradation of IκB-α in renal cells, indicating that the NF-κB signaling pathway was inhibited by YPR. Finally, the study suggests that YPR could significantly improve the renal function in SHR. The mechanism could be attributed to its inhibition of renal NF-κB signaling pathway and inflammation.