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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 6784689, 11 pages
http://dx.doi.org/10.1155/2016/6784689
Research Article

Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters

1Department of Basic Theory of Chinese Medicine, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China
2Department of Pathophysiology, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China
3Department of Pathophysiology, School of Preclinical Medicine, Sun Yat-Sen University, 58 Zhongshan Er Road, Guangzhou 510080, China

Received 16 January 2016; Revised 16 May 2016; Accepted 23 May 2016

Academic Editor: Maria Camilla Bergonzi

Copyright © 2016 Li-Li Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the present study was to investigate the antidepressant-like effects of two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH soluble fraction (Fraction B, FB) prepared from the Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. The results indicated that DZXYS could ameliorate the depression-like behavior in chronic stress model of rats. The inhibition of hyperactivity of HPA axis and the modulation of monoamine and amino acid neurotransmitters in the hippocampus may be the important mechanisms underlying the action of DZXYS antidepressant-like effect in chronically stressed rats.