Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling

<div>Berberine protects the HUVECs against LPS-induced injury by blocking the JNK signaling pathway. (a) Cell viability in HUVECs subjected to different treatments. (b) Micrographs of the fluorescence of nuclei in HUVECs subjected to different treatments. (c) The percentage of apoptotic cells in the cells subjected to different treatments. (d) The levels of MDA in HUVECs subjected to different treatments. (e) The activity of SOD in HUVECs subjected to different treatments. (f) The levels of TNF-<svg height="6.1673pt" id="M28" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 7.51131 6.1673" width="7.51131pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M545 106L524 126C493 85 467 65 455 65C438 65 427 113 405 238C448 295 498 362 543 439L533 448L478 435C453 386 423 331 398 295H395C370 404 347 448 282 448C169 448 23 309 23 153C23 54 65 -12 128 -12C203 -12 283 70 339 155H341C360 29 380 -12 411 -12C444 -12 491 11 545 106ZM333 204C265 95 210 54 169 54C137 54 113 96 113 171C113 302 191 405 252 405C301 405 318 306 333 204Z" id="g113-223"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="568" vert-adv-y="568"></glyph.data></g></svg> in HUVECs subjected to different treatments. (g) The levels of IL-6 in HUVECs subjected to different treatments. 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Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Berberine Protects Human Umbilical Vein Endothelial Cells against LPS-Induced Apoptosis by Blocking JNK-Mediated Signaling 