Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 7273940, 9 pages
http://dx.doi.org/10.1155/2016/7273940
Research Article

To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory

1Department of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou 510632, China
2Department of Chinese Herbal Medicines, Pharmacy College, Jinan University, Guangzhou 510632, China
3Biomaterial Laboratory of Guangdong Higher Education and Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China
4Shandong University of Traditional Chinese Medicine, Jinan 250355, China

Received 9 May 2016; Revised 26 July 2016; Accepted 14 August 2016

Academic Editor: Luciana Dini

Copyright © 2016 Hongjie Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Jiang, C. Zhang, H. Cao, K. Chan, and A. Lu, “The role of Chinese medicine in the treatment of chronic diseases in China,” Planta Medica, vol. 77, no. 9, pp. 873–881, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. China State Administration of Traditional Chinese Medicine, Chinese Materia Medica, Shanghai Scientific and Technical Publishers, Shanghai, China, 1999 (Chinese).
  3. X. Wu, H. You, and J. Jia, “Clinical features of drug-induced liver injury: a review of Chinese literatures 2003–2007,” Chinese Hepatology, vol. 13, no. 6, pp. 463–466, 2008 (Chinese). View at Google Scholar
  4. F. Li, G. Yao, R. Jin, and Z. Song, “Mechanism studies on hepatotoxicity of rats induced by Sophorae Tonkinensis Radix et Rhizoma in rat,” China Journal of Chinese Materia Medica, vol. 36, no. 13, pp. 1821–1823, 2011 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  5. Q. Zhou, Q. Zhang, and R. Jin, “Time-effect and dose-effect of Evodia rutaecarpa on hepatotoxicity in mice,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 17, no. 10, pp. 232–235, 2011 (Chinese). View at Google Scholar
  6. L. Zhang and E. Tang, “Initial analysis on the origin and category of the theory of Chinese herbal nature,” World Chinese Medicine, vol. 9, no. 8, pp. 998–1004, 2014 (Chinese). View at Google Scholar
  7. X. Gao, Chinese Materia Medica, China Press of Traditional Chinese Medicine, Beijing, China, 2002 (Chinese).
  8. J. Wang, T. Zhang, N. Zeng, and Z. Li, “Research and reflection on the theory of nature of Chinese herbal medicine,” Liaoning Journal of Traditional Chinese Medicine, vol. 35, no. 2, pp. 212–213, 2008 (Chinese). View at Google Scholar
  9. X. Lin and H. Jin, “Relationship between herbs with hepatotoxicity and its property,” Journal of Liaoning University of TCM, vol. 11, no. 1, pp. 57–58, 2009 (Chinese). View at Google Scholar
  10. B. Lu and R. Jia, “Correlations between hepatotoxicity and four properties, five tastes, meridian entry of Chinese materia medica,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 18, no. 4, pp. 268–271, 2012 (Chinese). View at Google Scholar
  11. Q. Wang, J. Si, R. Zhou, and T. He, Drug Induced Liver Disease, Military Medical Science Press, Beijing, China, 2010 (Chinese).
  12. L. Xia, Modern Chinese Herbal Medicines Toxicology, Tianjin Science & Technology Translation, Tianjin, China, 2005 (Chinese).
  13. Y. Ren, S. Zhang, W. Ni, K. Feng, and M. Ding, The Practical Encyclopedia of Acute Poisoning, People's Health Publishing Press, Beijing, China, 2003 (Chinese).
  14. C. Yang, Toxic Materia Medica, China Press of Traditional Chinese Medicine, Beijing, China, 1993 (Chinese).
  15. J. Yang and X. Pu, Modern Research and Application of Commonly Used Toxic Chinese Herbal Medicines, Science Press, Beijing, China, 2014 (Chinese).
  16. China State Administration of Traditional Chinese Medicine, Selected Edition of Chinese Materia Medica, Shanghai Scientific and Technical Publishers, Shanghai, China, 1998 (Chinese).
  17. J.-Y. Wang and J.-S. Guo, “Diagnosis and treatment of drug induced liver diseases,” Chinese Journal of Hepatology, vol. 12, no. 4, article 242, 2004. View at Google Scholar · View at Scopus
  18. Z. Sun and Y. Xu, Medical Statistics, People's Medical Publishing House, Beijing, China, 2010 (Chinese).
  19. L. Chen and L. Ji, Basic Theory of Traditional Chinese Medicine, Jinan University Press, Guangzhou, China, 2012 (Chinese).
  20. L. Ohno-Machado, “Modeling medical prognosis: survival analysis techniques,” Journal of Biomedical Informatics, vol. 34, no. 6, pp. 428–439, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. N. A. Obuchowski, “Receiver operating characteristic curves and their use in radiology,” Radiology, vol. 229, no. 1, pp. 3–8, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Yu, B. Wang, and M. Lu, “Morphological foundation of meridian entry of Chinese Materia Medica (part two),” Journal of Shanghai University of Traditional Chinese Medicine, vol. 20, pp. 32–36, 2006 (Chinese). View at Google Scholar
  23. J. Guan, H. Zhu, and W. Ma, Quantification and Application of Traditional Chinese Medicine Theory, People's Military Medical Press, Beijing, China, 2014 (Chinese).
  24. C. Chen, B. Wang, L. Yu, B. Jiang, L. Xu, and T. Fang, “Research on the hepatotoxicity of the chemical constituents in traditional Chinese medicine,” Pharmaceutical and Clinical Research, vol. 20, pp. 148–151, 2012 (Chinese). View at Google Scholar
  25. C. Thiel, K. Thiel, W. Klingert et al., “The enterohepatic circulation of amanitin: kinetics and therapeutical implications,” Toxicology Letters, vol. 203, no. 2, pp. 142–146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Li, Z. Yang, J. Xu, L.-H. Tang, X.-D. Wo, and D.-Z. Lu, “Effects of warm and heat Chinese herbs on liver mitochondria proteome of model rats with cold syndrome,” Chinese Traditional and Herbal Drugs, vol. 45, no. 3, pp. 373–379, 2014 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  27. E.-W. Hao, J.-G. Deng, Z.-C. Du et al., “Study on the regulation role of semen persicae to cAMP-PKA signal pathway in the rats with cold and heat blood stasis syndrome,” Journal of Chinese Medicinal Materials, vol. 36, no. 5, pp. 780–783, 2013 (Chinese). View at Google Scholar · View at Scopus
  28. A. Brunyanszki, G. Olah, C. Coletta, B. Szczesny, and C. Szabo, “Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress,” Molecular Pharmacology, vol. 86, no. 4, pp. 450–462, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. J. E. Leadsham and C. W. Gourlay, “cAMP/PKA signaling balances respiratory activity with mitochondria dependent apoptosis via transcriptional regulation,” BMC Cell Biology, vol. 11, no. 1, article 92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Felser, P. W. Lindinger, D. Schnell et al., “Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure,” Toxicology, vol. 324, pp. 136–146, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. M. P. C. Ribeiro, A. E. Santos, and J. B. A. Custódio, “Mitochondria: the gateway for tamoxifen-induced liver injury,” Toxicology, vol. 323, pp. 10–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Chen, F. Zhang, D. Kong et al., “Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity,” Chemico-Biological Interactions, vol. 206, no. 1, pp. 76–82, 2013. View at Publisher · View at Google Scholar
  33. Z. Lin, F. Wu, S. Lin et al., “Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice,” Journal of Hepatology, vol. 61, no. 4, pp. 825–831, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Liang, L. Li, M. Wang et al., “Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine,” Journal of Ethnopharmacology, vol. 148, no. 3, pp. 770–779, 2013. View at Publisher · View at Google Scholar · View at Scopus