Research Article
Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice
Table 1
UPLC-DAD/Q-TOF-MS identification of the bioactive constituents in JGT.
| Peak number | (min) | Identification | Mode | MS (m/z) | Error/ppm | MS/MS | Monoisotopic mass | Composition | Source |
| 1 | 4.2 | 2-(2-Hydroxyphenyl)-succinic acid | Neg. | 209.0509 | 1.96 | 209 [M − H]−; 165 [M − H − CO2]−; 129 [M − H − CO2 − 2H2O]−; 121 [M − H − 2CO2]− | 210.0528 | C10H10O5 | GU |
| 2 | 7.32 | Liquiritin apioside | Pos. | 551.1744 | −3.63 | 551 [M + H]+; 419 [M + H − api]+; 257 [M + H − api − glc]+ | 550.1686 | C26H30O13 | GU | Neg. | 549.1657 | 8.9 | 549 [M − H]−; 417 [M − H − api]−; 255 [M − H − api − glc]− |
| 3 | 7.57 | Liquiritin | Pos. | 419.1335 | 1.67 | 419 [M + H]+; 257 [M + H − glc]+ | 418.1264 | C21H22O9 | GU | Neg. | 417.1212 | 6.23 | 417 [M − H]−; 255 [M − H − glc]− |
| 4 | 8.36 | Platycogenic acid A | Neg. | 533.314 | 4.69 | 533 [M − H]− | 534.3193 | C30H46O8 | PG |
| 5 | 8.97 | Polygalacic acid | Pos. | 505.3437 | 8.72 | 505 [M + H] | 504.3451 | C30H48O6 | PG |
| 6 | 11.55 | Licorice-saponin J2 | Pos. | 825.427 | 0.24 | 825 [M + H]+; 649 [M + H − glu]+; 455 [M + H − glu − Glu]+ | 824.4194 | C42H64O16 | GU | Neg. | 823.418 | 7.77 | 823 [M − H]−; 351 [2 × C6H8O6 − H]−; 191 [C6H8O6 − H]− |
| 6′ | 11.95 | Platycodin D | Pos. | 1225.5932 | 6.64 | 1225 [M + H]+ | 1224.5775 | C57H92O28 | PG | Neg. | 1223.5737 | 3.27 | 1223 [M − H]−; 681 [M − C21H34O16]− |
| 7 | 13.27 | 22-β-Acetoxy-glycyrrhizic acid | Pos. | 881.4104 | 7.6 | 881 [M + H]+; 705 [M + H − glu]+; 511 [M + H − glu − Glu]+ | 880.4092 | C44H64O18 | GU | Neg. | 879.4095 | 9.10 | 879 [M − H]−; 351 [2 × C6H8O6 − H]− |
| 8 | 14.64 | Licorice-saponin G2 | Pos. | 839.4102 | 4.41 | 839 [M + H]+; 663 [M + H − glu]+; 469 [M + H − glu − Glu]+ | 838.3987 | C42H62O17 | GU | Neg. | 837.3927 | 2.15 | 837 [M − H]−; 819 [M − H − H2O]−; 351 [2 × C6H8O6 − H]− |
| 9 | 15.07 | 22-β-Acetoxyl-licorice-saponin C2 | Neg. | 863.4142 | 2.43 | 863 [M − H]−; 351 [2 × C6H8O6 − H]− | 864.4144 | C44H64O17 | GU |
| 10 | 15.55 | Glycyrrhizic acid | Pos. | 823.4043 | 8.86 | 823 [M + H]+; 647 [M + H − glu]+; 453 [M + H − glu − Glu]+ | 822.4038 | C42H62O16 | GU | Neg. | 821.3983 | 2.8 | 821 [M − H]−; 351 [2 × C6H8O6 − H]− |
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glc: glucose-H2O; Glu: glucuronide; glu: glucuronide-H2O; api: apiose-H2O.
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