Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs

Figure 9

Effect of UNCP (LD = 300, MD = 900, and HD = 1500 mg/kg) on nitrite concentrations in plasma of guinea pigs during A/L administration. Values are mean ± SD () and , , and compare to the control (one-way ANOVA followed by a Dunnett’s multiple comparison test). The low dose UNCP (300 mg/kg) + A/L produced the greatest increase (, , i.e., 149.71%) in nitric oxide followed by medium dose UNCP + A/L (, , i.e., 34.25%) and then high dose UNCP + A/L (, , i.e., 4.88%) when compared to the A/L only group.