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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7592705, 10 pages
Review Article

Efficacy of Chinese Herbal Medicine as an Adjunctive Therapy on in-Hospital Mortality in Patients with Acute Kidney Injury: A Systematic Review and Meta-Analysis

1Emergency Department, Affiliated Zhongshan Hospital of Dalian University, Dalian No. 6, Jiefang Street, Zhongshan District, Dalian, Liaoning 116001, China
2Dalian Medical University, Lvshunkou District, Dalian, Liaoning 116044, China
3College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, China

Received 9 December 2015; Revised 24 February 2016; Accepted 16 March 2016

Academic Editor: Kieran Cooley

Copyright © 2016 Tuo Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. We aimed to systematically assess the efficacy of Chinese herbal medicine (CHM) as an adjunctive therapy on in-hospital mortality in patients with acute kidney injury (AKI). Methods. We did a systematic review of articles published in any language up until Jun 23, 2015, by searching PubMed, Embase, the Cochrane Library, CBM, and CNKI. We included all RCTs that compared outcomes of patients with AKI taking CHM plus Western treatment (WT) with those taking WT alone. We applied Cochrane risk-of-bias tool to assess the methodological quality of the included trials. Results. Of 832 citations, 15 studies involving 966 patients met inclusion criteria. The methodological quality was assessed with unclear risk of bias. In the primary outcome of meta-analysis, pooled outcome of in-hospital mortality showed that patients randomly assigned to CHM treatment group were associated with low risk of in-hospital mortality compared with those randomly assigned to WT alone (RR = 0.41; 95% CI = 0.24 to 0.71; ). Conclusions. CHM as an adjunctive therapy is associated with a decreased risk of in-hospital mortality compared with WT in patients with AKI. Further studies with high quality and large sample size are needed to verify our conclusions.