Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 7603746, 9 pages
http://dx.doi.org/10.1155/2016/7603746
Research Article

Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents

College of Life Science, Northeast Forestry University, Harbin 150040, China

Received 15 December 2015; Revised 24 February 2016; Accepted 13 March 2016

Academic Editor: Ghee T. Tan

Copyright © 2016 Weiyu Zhang and Li Hua Jin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Genc, Z. Zadeoglulari, S. H. Fuss, and K. Genc, “The adverse effects of air pollution on the nervous system,” Journal of Toxicology, vol. 2012, Article ID 782462, 23 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Matus, K.-M. Nam, N. E. Selin, L. N. Lamsal, J. M. Reilly, and S. Paltsev, “Health damages from air pollution in China,” Global Environmental Change, vol. 22, no. 1, pp. 55–66, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. K. T. Palmer, R. McNeill-Love, J. R. Poole et al., “Inflammatory responses to the occupational inhalation of metal fume,” European Respiratory Journal, vol. 27, no. 2, pp. 366–373, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Zhefeng, C. Qiongjie, F. Yuqi et al., “Research on effects of cadmium induced intestinal epithelial cell injury and regulation on intestinal stem cells regeneration and differentiation in Drosophila mid-gut,” Chinese Journal of Cell Biology, vol. 35, no. 5, pp. 602–608, 2013. View at Google Scholar
  5. N. Buchon, N. A. Broderick, S. Chakrabarti, and B. Lemaitre, “Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila,” Genes and Development, vol. 23, no. 19, pp. 2333–2344, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Royet, “Epithelial homeostasis and the underlying molecular mechanisms in the gut of the insect model Drosophila melanogaster,” Cellular and Molecular Life Sciences, vol. 68, no. 22, pp. 3651–3660, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. W. S. Garrett, J. I. Gordon, and L. H. Glimcher, “Homeostasis and inflammation in the intestine,” Cell, vol. 140, no. 6, pp. 859–870, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. N. B. Samad, T. Debnath, A. Hasnat et al., “Phenolic contents, antioxidant and anti-inflammatory activities of Asparagus cochinchinensis (Loureiro) Merrill,” Journal of Food Biochemistry, vol. 38, no. 1, pp. 83–91, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Park, M. S. Cheon, S. H. Kim et al., “Anticancer activity of Asparagus cochinchinensis extract and fractions in HepG2 cells,” Journal of Applied Biological Chemistry, vol. 54, no. 2, pp. 188–193, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J. M. Chun, M. S. Cheon, B. C. Moon, A. Y. Lee, B. K. Choo, and H. K. Kim, “Anti-tumor activity of the ethyl acetate fraction from Asparagus cochinchinensis in HepG2-xenografted nude mice,” Journal of the Korean Society for Applied Biological Chemistry, vol. 54, no. 4, pp. 538–543, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. T. E. Lloyd and J. P. Taylor, “Flightless flies: Drosophila models of neuromuscular disease,” Annals of the New York Academy of Sciences, vol. 1184, pp. E1–E20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. S. Dionne and D. S. Schneider, “Models of infectious diseases in the fruit fly Drosophila melanogaster,” Disease Models and Mechanisms, vol. 1, no. 1, pp. 43–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Vidal and R. L. Cagan, “Drosophila models for cancer research,” Current Opinion in Genetics and Development, vol. 16, no. 1, pp. 10–16, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. M. E. Fortini and N. M. Bonini, “Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer,” Trends in Genetics, vol. 16, no. 4, pp. 161–167, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Leopold and N. Perrimon, “Drosophila and the genetics of the internal milieu,” Nature, vol. 450, no. 7167, pp. 186–188, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Pitsouli, Y. Apidianakis, and N. Perrimon, “Homeostasis in infected epithelia: stem cells take the lead,” Cell Host & Microbe, vol. 6, no. 4, pp. 301–307, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. D. C. Rubin, “Intestinal morphogenesis,” Current Opinion in Gastroenterology, vol. 23, no. 2, pp. 111–114, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Apidianakis and L. G. Rahme, “Drosophila melanogaster as a model for human intestinal infection and pathology,” Disease Models and Mechanisms, vol. 4, no. 1, pp. 21–30, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Gladstone and T. T. Su, “Chemical genetics and drug screening in Drosophila cancer models,” Journal of Genetics and Genomics, vol. 38, no. 10, pp. 497–504, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Gonzalez, “Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics,” Nature Reviews Cancer, vol. 13, no. 3, pp. 172–183, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Li, Q. Luo, and L. H. Jin, “Acanthopanax senticosus extracts have a protective effect on Drosophila gut immunity,” Journal of Ethnopharmacology, vol. 146, no. 1, pp. 257–263, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Zhu, F. Guan, C. Wang, and L. H. Jin, “The protective effects of Rhodiola crenulata extracts on Drosophila melanogaster gut immunity induced by bacteria and SDS toxicity,” Phytotherapy Research, vol. 28, no. 12, pp. 1861–1866, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Gu, Y. Gui, L. Chen, G. Yuan, H.-Z. Lu, and X. Xu, “Use of natural products as chemical library for drug discovery and network pharmacology,” PLoS ONE, vol. 8, no. 4, Article ID e62839, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Knox, V. Law, T. Jewison et al., “DrugBank 3.0: a comprehensive resource for “Omics” research on drugs,” Nucleic Acids Research, vol. 39, no. 1, pp. D1035–D1041, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. X. Liu, S. Ouyang, B. Yu et al., “PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach,” Nucleic Acids Research, vol. 38, no. 2, pp. W609–W614, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Shannon, A. Markiel, O. Ozier et al., “Cytoscape: a software Environment for integrated models of biomolecular interaction networks,” Genome Research, vol. 13, no. 11, pp. 2498–2504, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Buchon, N. A. Broderick, M. Poidevin, S. Pradervand, and B. Lemaitre, “Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation,” Cell Host & Microbe, vol. 5, no. 2, pp. 200–211, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Gupta, M. Athar, J. R. Behari, and R. C. Srivastava, “Cadmium-mediated induction of cellular defence mechanism: a novel example for the development of adaptive response against a toxicant,” Industrial Health, vol. 29, no. 1, pp. 1–9, 1991. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Li, X. Xu, J. Wang et al., “A system-level investigation into the mechanisms of chinese traditional medicine: compound danshen formula for cardiovascular disease treatment,” PLoS ONE, vol. 7, no. 9, Article ID e43918, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Liu, D. Lu, H. Zhang et al., “Applying high-performance computing in drug discovery and molecular simulation,” National Science Review, vol. 3, no. 1, pp. 49–63, 2016. View at Publisher · View at Google Scholar
  31. X. Liu, Z. Hu, B. Zhou, X. Li, and R. Tao, “Chinese herbal preparation xuebijing potently inhibits inflammasome activation in hepatocytes and ameliorates mouse liver ischemia-reperfusion injury,” PLoS ONE, vol. 10, no. 7, Article ID e0131436, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Todeschini and V. Consonni, Handbook of Molecular Descriptors, John Wiley & Sons, New York, NY, USA, 2008.
  33. J. Li, X. Liu, M. Guo, Y. Liu, S. Liu, and S. Yao, “Electrochemical study of breast cancer cells MCF-7 and its application in evaluating the effect of diosgenin,” Analytical Sciences, vol. 21, no. 5, pp. 561–564, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Corbiere, B. Liagre, A. Bianchi et al., “Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells,” International Journal of Oncology, vol. 22, no. 4, pp. 899–905, 2003. View at Google Scholar · View at Scopus
  35. B. Liagre, J. Bertrand, D. Y. Leger, and J.-L. Beneytout, “Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding,” International Journal of Molecular Medicine, vol. 16, no. 6, pp. 1095–1101, 2005. View at Google Scholar · View at Scopus
  36. D. Y. Lee, B. K. Choo, T. Yoon et al., “Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation,” Journal of Ethnopharmacology, vol. 121, no. 1, pp. 28–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Wang, B. Waltenberger, E.-M. Pferschy-Wenzig et al., “Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review,” Biochemical Pharmacology, vol. 92, no. 1, pp. 73–89, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. I. Szatmari, E. Rajnavolgyi, and L. Nagy, “PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function,” Annals of the New York Academy of Sciences, vol. 1088, pp. 207–218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Széles, D. Töröcsik, and L. Nagy, “PPARγ in immunity and inflammation: cell types and diseases,” Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1771, no. 8, pp. 1014–1030, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. W. Huang and C. K. Glass, “Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 8, pp. 1542–1549, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. C. K. Glass and K. Saijo, “Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells,” Nature Reviews Immunology, vol. 10, no. 5, pp. 365–376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. W.-Y. Tsui and G. D. Brown, “(+)-Nyasol from Asparagus cochinchinensis,” Phytochemistry, vol. 43, no. 6, pp. 1413–1415, 1996. View at Publisher · View at Google Scholar · View at Scopus
  43. H. J. Lee, H. Li, H. R. Chang, H. Jung, D. Y. Lee, and J.-H. Ryu, “(−)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 28, no. 5, pp. 954–959, 2013. View at Publisher · View at Google Scholar · View at Scopus