A 70% Ethanol Extract of Mistletoe Rich in Betulin, Betulinic Acid, and Oleanolic Acid Potentiated β-Cell Function and Mass and Enhanced Hepatic Insulin Sensitivity

Figure 1

Changes in serum glucose concentrations during the oral glucose tolerance test. Oral glucose tolerance tests were performed on Px rats fed high-fat diets supplemented with either (1) 0.6% water extract of Korean mistletoe (KMW-W), (2) 0.6% of 70% ethanol extract of Korean mistletoe (KME-E), or (3) 0.6% dextrose (Px-control). As a normal-control group, sham-operated rats were provided with a high-fat diet containing 0.6% dextrose. After 8 weeks of treatment, glucose (2 g/kg body weight) was administered orally, blood samples were taken at the indicated time points, and serum glucose levels were measured. The sample size of each group was the same as in Table 2. The dots and error bars represent mean ± SD. Values on the bars with different superscripts were significantly different in a Tukey post hoc test at a significance of .