Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 7930563, 9 pages
http://dx.doi.org/10.1155/2016/7930563
Research Article

Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl

1Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil
2Phytopathology Laboratory, Embrapa Agroindústria Tropical (EMBRAPA), Federal University of Ceará, Campus do Pici, 60455-970 Fortaleza, CE, Brazil
3Degree Course in Biological Sciences, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, 64049-550 Teresina, PI, Brazil
4Course of Chemistry, State University of Ceará, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil
5Biotechnology and Molecular Biology Laboratory, State University of Ceará, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil

Received 15 March 2016; Revised 19 April 2016; Accepted 20 April 2016

Academic Editor: Felice Senatore

Copyright © 2016 Paulo Fernando Machado Paredes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Lorenzi and F. J. A. Matos, Plantas Medicinais no Brasil: Nativas e Exóticas, Instituto Plantarum, Nova Odessa, Brazil, 2nd edition, 2008.
  2. M. C. M. Amorozo, “Pluralistic medical settings and medicinal plant use in rural communities, Mato Grosso, Brazil,” Journal of Ethnobiology, vol. 24, no. 1, pp. 139–161, 2004. View at Google Scholar
  3. C. A. A. López, “Considerações gerais sobre plantas medicinais,” Ambiente: Gestão e Desenvolvimento, vol. 1, no. 1, pp. 19–27, 2006. View at Google Scholar
  4. Ministério da Saúde, Secretaria de Ciência Tecnologia e Insumos Estratégicos, and Departamento de Assistência Farmacêutica e Insumos Estratégicos, A Fitoterapia no SUS e o Programa de Pesquisas de Plantas Medicinais da Central de Medicamentos, Ministério da Saúde, Itaperuna, Brazil, 2006.
  5. P. M. Guerra and O. R. Nodari, “Biodiversidade: aspectos biológicos, geográficos, legais e éticos,” in Farmacognosia: Da Planta ao Medicamento, C. M. O. Simões, E. P. Schenkel, G. Gosmann, J. C. P. Mello, L. A. Mentz, and P. R. Petrovick, Eds., p. 15, UFRGS, Florianópolis, Brazil, UFSC, Porto Alegre, Brazil, 3rd edition, 2001. View at Google Scholar
  6. A. Salgado, “Alta do dólar freia o setor farmacêutico,” Brasil Econômico, 2015, http://brasileconomico.ig.com.br/brasil/economia/2015-03-20/alta-do-dolar-freia-o-setor-farmaceutico.html. View at Google Scholar
  7. REUTERS, Brasil Terá Primeiro Banco de Dados de Plantas Medicinais, Folha Online, São Paulo, Brazil, 2002, http://www.uol.com.br/folha/reuters/ult112u12329.shl.
  8. H. Schistek, “Caatinga: um bioma exclusivamente brasileiro... e o mais frágil,” Revista do Instituto de Humanitas Usininos, no. 389, pp. 1–60, 2012. View at Google Scholar
  9. U. P. Albuquerque and L. D. H. C. Andrade, “Conhecimento botânico tradicional e conservação em uma área de caatinga no estado de Pernambuco, Nordeste do Brasil,” Acta Botanica Brasilica, vol. 16, no. 3, pp. 273–285, 2002. View at Publisher · View at Google Scholar
  10. U. P. Albuquerque and R. F. P. Lucena, Métodos e Técnicas de Pesquisa Etnobotânica, Livro Rápido/NUPEEA, Recife, Brazil, 2004.
  11. D. A. Lima, Plantas da Caatinga, Academia Brasileira de Ciências, 1989.
  12. M. B. R. Silva, M. W. Souza, E. C. S. Melo, J. A. Pontes, F. A. M. Saraiva, and A. M. Correia, “Transpiração de três espécies nativas do semi-árido em condições de campo,” Revista Atmosfera e Água, vol. 5, pp. 52–58, 2000. View at Google Scholar
  13. J. G. Duque, O Nordeste e as Lavouras Xerófilas, Banco do Nordeste do Brasil, 4th edition, 2004.
  14. J. L. L. de la Luz, E. Troyo-Diéguez, M. M. Ortega-Nieblas, and F. López-Gutiérrez, “‘Caribe’ (Cnidoscolus angustidens Torr.), a promising oilseed geophyte from north-west Mexico,” Journal of Arid Environments, vol. 41, no. 3, pp. 299–308, 1999. View at Publisher · View at Google Scholar
  15. V. V. Ribeiro and N. M. Brito, “Fungos associados a sementes de Cnidoscolus quercifolius Pohl et baile em épocas distintas,” BioFar, vol. 4, no. 1, pp. 73–76, 2010. View at Google Scholar
  16. F. J. A. Mattos, Introdução à Fitoquímica Experimental, Edições UFC, Fortaleza, Brazil, 2009.
  17. W. Brand-Williams, M. E. Cuvelier, and C. Berset, “Use of a free radical method to evaluate antioxidant activity,” LWT—Food Science and Technology, vol. 28, no. 1, pp. 25–30, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. A. W. Bauer, W. M. M. Kirby, J. C. Sherris, and M. Turck, “Antibiotic susceptibility testing by a standardized single disk method,” American Journal of Clinical Pathology, vol. 36, pp. 493–496, 1966. View at Google Scholar
  19. Clinical and Laboratory Standards Institute (CLSI) Document, “Reference methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standards-6th ed,” Document M7—A6 Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute (CLSI), Wayne, Pa, USA, 2006. View at Google Scholar
  20. M. T. N. Silva, P. I. Ushimaru, L. N. Barbosa, M. L. R. S. Cunha, and A. Fernandes Junior, “Atividade antibacteriana de óleos essenciais de plantas frente a linhagens de Staphylococcus aureus e Escherichia coli isoladas de casos clínicos humanos,” Revista Brasileira de Plantas Medicinais, vol. 11, no. 3, pp. 257–262, 2009. View at Publisher · View at Google Scholar
  21. G. L. Ellman, K. D. Courtney, V. Andres Jr., and R. M. Featherstone, “A new and rapid colorimetric determination of acetylcholinesterase activity,” Biochemical Pharmacology, vol. 7, pp. 88–95, 1961. View at Google Scholar
  22. I. K. Rhee, M. Van De Meent, K. Ingkaninan, and R. Verpoorte, “Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining,” Journal of Chromatography A, vol. 915, no. 1-2, pp. 217–223, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. S. M. De Morais, K. S. B. Lima, S. M. C. Siqueira et al., “Correlação entre as atividades antiradical, antiacetilcolinesterase e teor de fenóis totais de extratos de plantas medicinais de farmácias vivas,” Revista Brasileira de Plantas Medicinais, vol. 15, no. 4, pp. 575–582, 2013. View at Publisher · View at Google Scholar
  24. M. T. S. Trevisan, F. V. V. Macedo, M. V. Meent, I. K. Rhee, and R. Verpoorte, “Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer,” Química Nova, vol. 26, no. 3, pp. 301–304, 2003. View at Publisher · View at Google Scholar
  25. B. N. Meyer, N. R. Ferrigni, J. E. Putnam, L. B. Jacobsen, D. E. Nichols, and J. L. McLaughlin, “Brine shrimp: a convenient general bioassay for active plant constituents,” Planta Medica, vol. 45, no. 1, pp. 31–34, 1982. View at Publisher · View at Google Scholar · View at Scopus
  26. T. J. S. Peixoto Sobrinho, V. T. N. A. Castro, A. M. Saraiva et al., “Phytochemical screening and antibacterial activity of four Cnidoscolus species (Euphorbiaceae) against standard strains and clinical isolates,” Journal of Medicinal Plant Research, vol. 6, no. 21, pp. 3742–3748, 2012. View at Google Scholar
  27. L. M. De Araújo Gomes, T. M. D. De Andrade, J. C. Silva, J. T. De Lima, L. J. Quintans-Junior, and J. R. G. Da Silva Almeida, “Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice,” Pharmacognosy Research, vol. 6, no. 4, pp. 345–349, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. O. A. Awoyinka, I. O. Balogun, and A. A. Ogunnowo, “Phytochemical screening and in vitro bioactivity of Cnidoscolus aconitifolius (Euphorbiaceae),” Journal of Medicinal Plants Research, vol. 1, pp. 63–65, 2007. View at Google Scholar
  29. S. H. Rouse and R. Bienfang, “A note on the phytochemical study of the root of Cnidoscolus texanus (Muell. Arg.) Small,” Journal of the American Pharmaceutical Association, vol. 43, no. 11, pp. 699–700, 1954. View at Publisher · View at Google Scholar · View at Scopus
  30. M. T. Yakubu, M. A. Akanji, A. T. Oladiji et al., “Effect of Cnidoscolous aconitifolius (Miller) IM Johnston leaf extract on reproductive hormones of female rats. Iran,” The Journal of Reproductive Medicine, vol. 6, pp. 149–155, 2008. View at Google Scholar
  31. M. A. M. Maciel, A. C. Pinto, and V. F. Veiga Jr., “Plantas medicinais: a necessidade de estudos multidisciplinares,” Química Nova, vol. 25, no. 3, pp. 429–438, 2002. View at Google Scholar
  32. L. Gobbo-Neto and N. P. Lopes, “Plantas medicinais: fatores de influência no conteúdo de metabólitos secundários,” Química Nova, vol. 30, no. 2, pp. 374–381, 2007. View at Publisher · View at Google Scholar
  33. T. M. Kutchan, “Ecological arsenal and developmental dispatcher. The paradigm of secondary metabolism,” Plant Physiology, vol. 125, no. 1, pp. 58–60, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. C. M. M. Sousa, H. R. e Silva, G. M. Vieira Jr. et al., “Fenóis totais e atividade antioxidante de cinco plantas medicinais,” Química Nova, vol. 30, no. 2, pp. 351–355, 2007. View at Google Scholar
  35. J. I. E. Guerra, “Oxidative stress, diseases and antioxidant treatment,” Anales de Medicina Interna, vol. 18, no. 6, pp. 326–335, 2001. View at Google Scholar · View at Scopus
  36. D. M. Almeida and E. L. C. Amorim, “Estudo químico de duas espécies do gênero cnidoscolus presentes no bioma caatinga com potencial atividade antioxidante,” in Congresso de Iniciação Científica, I Congresso de Iniciação em Desenvolvimento Tecnológico e Inovação, UFPE/CTG, Recife, Brazil, 2009. View at Google Scholar
  37. F. Conforti, S. Sosa, M. Marrelli et al., “The protective ability of Mediterranean dietary plants against the oxidative damage: the role of radical oxygen species in inflammation and the polyphenol, flavonoid and sterol contents,” Food Chemistry, vol. 112, no. 3, pp. 587–594, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. George and P. Chaturvedi, “Protective role of Ocimum canum plant extract in alcohol-induced oxidative stress in albino rats,” British Journal of Biomedical Science, vol. 65, no. 2, pp. 80–85, 2008. View at Google Scholar · View at Scopus
  39. S. E. Lee, H. J. Hwang, J.-S. Ha, H.-S. Jeong, and J. H. Kim, “Screening of medicinal plant extracts for antioxidant activity,” Life Sciences, vol. 73, no. 2, pp. 167–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Vijayakumar, R. Govindarajan, G. M. M. Rao et al., “Action of Hygrophila auriculata against streptozotocin-induced oxidative stress,” Journal of Ethnopharmacology, vol. 104, no. 3, pp. 356–361, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. I. Urquiaga and F. Leighton, “Plant polyphenols, antioxidants and oxidative stress,” Biological Research, vol. 33, no. 2, pp. 55–64, 2000. View at Google Scholar
  42. F. B. Holetz, G. L. Pessini, N. R. Sanches, D. A. G. Cortez, C. V. Nakamura, and B. P. Dias Filho, “Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases,” Memorias do Instituto Oswaldo Cruz, vol. 97, no. 7, pp. 1027–1031, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. S. G. A. Almeida, Estudo do Potencial Antimicrobiano e Antiproliferativo do Extrato da Planta Cnidoscolus quercifolius Pohl (Favela), Universidade Estadual da Paraíba, Centro de Ciências Biológicas e da Saúde, 2013.
  44. I. Ahmad and A. Z. Beg, “Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens,” Journal of Ethnopharmacology, vol. 74, no. 2, pp. 113–123, 2001. View at Publisher · View at Google Scholar · View at Scopus
  45. V. V. Ribeiro, Efeitos de Fungicida e Produtos Naturais Sobre o Desenvolvimento de Fusarium oxysporum f. sp. Tracheiphilum em Sementes de Caupi, Universidade Federal da Paraíba- Centro de Ciências Agrárias, Rio Tinto, Portugal, 2008.
  46. I. Orhan, B. Şener, M. I. Choudhary, and A. Khalid, “Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants,” Journal of Ethnopharmacology, vol. 91, no. 1, pp. 57–60, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Adsersen, B. Gauguin, L. Gudiksen, and A. K. Jäger, “Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity,” Journal of Ethnopharmacology, vol. 104, no. 3, pp. 418–422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Ingkaninan, P. Temkitthawon, K. Chuenchom, T. Yuyaem, and W. Thongnoi, “Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies,” Journal of Ethnopharmacology, vol. 89, no. 2-3, pp. 261–264, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. P. K. Mukherjee, V. Kumar, M. Mal, and P. J. Houghton, “Acetylcholinesterase inhibitors from plants,” Phytomedicine, vol. 14, no. 4, pp. 289–300, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. M.-J. R. Howes and P. J. Houghton, “Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function,” Pharmacology Biochemistry and Behavior, vol. 75, no. 3, pp. 513–527, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. J. L. McLaughlin, “Crown gall tumours on potato discs and brine shrimp lethality: two simple bioassays for higher plant screening and fractions,” in Methods in Plant Biochemistry, P. M. Dey and J. B. Harbone, Eds., pp. 1–32, Academic Press, New York, NY, USA, 1991. View at Google Scholar
  52. M. Falkenberg, D. Baumgarten, and C. Simionato, “Screening of some Brazilian medicinal plants with the brine shrimp assay,” Acta Horticulturae, vol. 502, pp. 401–404, 1999. View at Google Scholar · View at Scopus
  53. A. L. T. G. Ruiz, E. G. Magalhães, A. F. Magalhães et al., “Avaliação da atividade tóxica em Artemia salina e Biomphalaria glabrata de extratos de quatro espécies do gênero Eleocharis (Cyperaceae),” Revista Brasileira de Farmacognosia, vol. 15, no. 2, pp. 98–102, 2005. View at Publisher · View at Google Scholar
  54. T. M. De Almeida Alves, A. F. Silva, M. Brandão et al., “Biological screening of Brazilian medicinal plants,” Memórias do Instituto Oswaldo Cruz, vol. 95, no. 3, pp. 367–373, 2000. View at Publisher · View at Google Scholar · View at Scopus
  55. A. J. Souza, Estudo Fitoquímico e Atividade Biológica In Vitro de Cnidoscolus urens L. (Arthur) (EUPHORBIACEAE), Universidade Federal do Vale do São Francisco, Petrolina, Brazil, 2014.
  56. J. L. McLaughlin, C. J. Chang, and D. L. Smith, “Bench-top bioassays for the discovery of bioactive natural products: an update,” in Studies in Natural Products Chemistry, A. Rahman, Ed., pp. 383–409, Elsevier, 9th edition, 1991. View at Google Scholar
  57. R. L. Fabri, D. S. De Sá, A. P. O. Pereira, E. Scio, D. S. Pimenta, and L. M. Chedier, “Antimicrobial, antioxidant and cytotoxicity potential of Manihot multifida (L.) Crantz (Euphorbiaceae),” Anais da Academia Brasileira de Ciências, vol. 87, no. 1, pp. 303–311, 2015. View at Publisher · View at Google Scholar · View at Scopus