Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 8034263, 4 pages
http://dx.doi.org/10.1155/2016/8034263
Research Article

Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia

Department of Traditional Chinese Medicine, Chinese People’s Liberation Army General Hospital, Beijing 100853, China

Received 15 April 2016; Revised 25 July 2016; Accepted 9 August 2016

Academic Editor: Bhushan Patwardhan

Copyright © 2016 Fagen Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Winkler, C. Auer, B. K. Doering, and W. Rief, “Drug treatment of primary insomnia: A meta-analysis of polysomnographic randomized controlled trials,” CNS Drugs, vol. 28, no. 9, pp. 799–816, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. S. D. Li, D. F. Zhou, F. G. Li et al., “Hormonizing stomach and calming nerves method for insomnia: clinical research,” Beijing Journal of Traditional Chinese Medicine, vol. 33, no. 11, pp. 807–808, 2014. View at Google Scholar
  3. H.-O. Luo, S.-D. Li, M.-H. Yang, D.-Y. Li, and H. Zhao, “Effect of Hewei Anshen Tang on quality of sleep and life of patients with insomnia,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 18, no. 6, pp. 18–20, 2011. View at Google Scholar
  4. D. Y. Li, R. Mei, S. D. Li et al., “Clinical study on people with primary insomnia treated by TCM of Harmonizing Stomach to Tranquilize,” Global Traditional Chinese Medicine, vol. 5, no. 8, pp. 585–587, 2012. View at Google Scholar
  5. C. R. Xiao, Z. C. Ma, H. J. Li et al., “The establishment and mechanism of insomnia rat model by PCPA,” Journal of Toxicology, vol. 21, no. 4, article 326, 2007. View at Google Scholar
  6. M. Yu, C. L. Tang, Z. L. Liu et al., “Effect of electroacupuncture intensity on orexin-A expression in hypothalamus of insomnia rats,” Journal of Medical Molecular Biology, vol. 8, no. 1, pp. 70–74, 2011. View at Google Scholar
  7. L. De Lecea, T. S. Kilduff, C. Peyron et al., “The hypocretins: hypothalamus specific peptides neyroexcitatory actitity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 1, pp. 322–327, 1998. View at Google Scholar
  8. T. Sakurai, A. Amemiya, M. Ishii et al., “Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior,” Cell, vol. 92, no. 4, pp. 573–585, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Tsujino and T. Sakurai, “Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system,” Pharmacological Reviews, vol. 61, no. 2, pp. 162–176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. R. Adamantidis, F. Zhang, A. M. Aravanis, K. Deisseroth, and L. De Lecea, “Neural substrates of awakening probed with optogenetic control of hypocretin neurons,” Nature, vol. 450, no. 7168, pp. 420–424, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. L. I. Kiyashchenko, B. Y. Mileykovskiy, N. Maidment et al., “Release of hypocretin (orexin) during waking and sleep states,” The Journal of Neuroscience, vol. 22, no. 13, pp. 5282–5286, 2002. View at Google Scholar · View at Scopus
  12. H. Chang, T. Saito, N. Ohiwa et al., “Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats,” Neuroscience Research, vol. 57, no. 3, pp. 462–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. E. D. Cid-Pellitero and M. Garzón, “Hypocretin1/OrexinA-containing axons innervate locus coeruleus neurons that project to the Rat medial prefrontal cortex. Implication in the sleep-wakefulness cycle and cortical activation,” Synapse, vol. 65, no. 9, pp. 843–857, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Michelson, E. Snyder, E. Paradis et al., “Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial,” The Lancet Neurology, vol. 13, no. 5, pp. 461–471, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Hadjiivanova, S. Belcheva, and I. Belcheva, “Cholecystokinin and learning and memory processes,” Acta Physiologica et Pharmacologica Bulgarica, vol. 27, no. 2-3, pp. 83–88, 2003. View at Google Scholar · View at Scopus
  16. F. Crespi, “Cholecystokinin-B (CCK-B) receptor antagonists improve ‘aged’ sleep: a new class of sleep modulators?” Methods and Findings in Experimental and Clinical Pharmacology, vol. 21, no. 1, pp. 31–38, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Shemyakin and L. Kapás, “L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 280, no. 5, pp. R1420–R1426, 2001. View at Google Scholar · View at Scopus
  18. G. Kronenberg, M. Schredl, K. Fiedler, and I. Heuser, “In healthy volunteers responses to challenge with cholecystokinin tetrapeptide differ between administration during REM and delta sleep,” Depression and Anxiety, vol. 14, no. 2, pp. 141–144, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Kapás, F. Obál Jr., M. R. Opp, L. Johannsen, and J. M. Krueger, “Intraperitoneal injection of cholecystokinin elicits sleep in rabbits,” Physiology & Behavior, vol. 50, no. 6, pp. 1241–1244, 1991. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Lanza and F. Makovec, “Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCKB receptors located on glutamatergic interneurons,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 361, no. 1, pp. 33–38, 2000. View at Publisher · View at Google Scholar · View at Scopus