Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Tab 1

Review Article

Assessment of the Therapeutic Effect of Total Glucosides of Peony for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis

Table 1

Characteristic of included studies.

StudyCase number (I/C)Age (years)Sex (male/female)Subtype of JIAIntervention (I)Control (C)OutcomesDuration

Shi and Ding (2004) [24]18/13UnclearUnclearUnclearTGP 0.9 g/d, oral.MTX 10 mg/m2/w, oralOverall response rate, AE6 W, 24 W

Tang et al. (2004) [25]16/16 9.517/15UnclearTGP 30–60 mg/kg/d, oral. Naproxen 10–12 mg/kg/d, prednisone 1-2 mg/kg/d, oral.Naproxen 10–12 mg/kg/d, prednisone 1-2 mg/kg/d, oralOverall response rate, autoantibody2 M

Zang (2004) [26]42/268.6 (3–14)32/36Poly 34, Pauci 18, and systemic 16TGP 0.03–0.06 g/kg/d, oral.MTX 0.2–0.4 mg/kg/w, oralOverall response rate, ESR, CRP, DMS, prednisone dosage, prednisone treatment duration, pain score, and AE6 M

Cao et al. (2006) [27]40/409.5 ± 3.052/28Pauci 25, poly 11, and systemic 44TGP 0.018 g/kg, twice a day orally; MTX 10 mg/m2 and folic acid 5 mg, once a week orally.MTX 10 mg/m2 and folic acid 5 mg, once a week orallyOverall response rate, AE8 W, 24 W

Li et al. (2008) [28]18/187.1 ± 2.6UnclearUnclearTGP 0.015 g/kg, twice a day orally, MTX 10 mg/m2, and folic acid 5 mg, once a week orally.MTX 10 mg/m2 and folic acid 5 mg, once a week orallyESR, CRP, DMS, TJC, and SJC8 W, 12 W

Liu (2008) [29]35/358.641/29Systemic 70TGP + MTX, oral dose (unclear).MTX, oral dose (unclear)Overall response rate, CRP, ESR, prednisone dosage, and prednisone treatment duration6 M

Tong and Shui (2009) [30]42/423–1538/46UnclearTGP 15–30 mg/kg, twice a day orally, Lef 0.2–0.4 mg/kg, and Mel 5–7.5 mg, once a week orally.Lef 0.2–0.4 mg/kg, Mel 5–7.5 mg, once a week orallyOverall response rate, CRP, ESR, DMS, and GS6 M

Sun (2011) [31]26/257.8 (1.5–14)24/27UnclearTGP 30–60 mg/kg/d, oral. MTX 10 mg/m2/w, oral.MTX 10 mg/m2/w, oralOverall response rate, CRP, ESR, DMS, TJC, SJC, and AE26 W

Zhao and Li (2011) [32]17/158.1 ± 2.518/14Poly 15, Pauci 10, and other 7TGP 0.3 g, twice a day orally, MTX 10 mg/m2, once a week orally.MTX 10 mg/m2 once a week orallyOverall response rate, CRP, and ESR6 M, 12 M

Fang and Li (2012) [33]23/228.1 ± 2.526/19Systemic 45TGP 0.3 g, twice a day orally, MTX 10 mg/m2, once a week orally.MTX 10 mg/m2 once a week orallyOverall response rate, CRP, and ESR6 M, 12 M

Wang (2012) [34]31/3010.6 ± 2.938/23Pauci 46, poly 13, and systemic 2TGP 0.6 g, 3 times a day orally, MTX 0.25–0.8 mg/kg, once a week orally.MTX 0.25–0.8 mg/kg, once a week orallyOverall response rate, CRP, ESR, DMS, autoantibody, ACR70, JADAS, and AE8 W, 12 W

Pauci: pauciarticular; poly: polyarticular; Lef: Leflunomide; Mel: meloxicam; DMS: duration of morning stiffness; TGP: total glucosides of peony; MTX: Methotrexate; TJC: tender joint count; SJC: swollen joint count; GS: grip strength; AE: adverse effect; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; JADAS: Juvenile Arthritis Disease Activity Score.

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