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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 8540640, 10 pages
http://dx.doi.org/10.1155/2016/8540640
Research Article

Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line

1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Tabriz University of Medical Sciences, International Branch of Aras, Tabriz, Iran
3Medical Plant Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Pharmacognosy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
5Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Received 18 November 2015; Revised 20 January 2016; Accepted 27 January 2016

Academic Editor: Victor Kuete

Copyright © 2016 Mona Orangi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Pooneh Chokhachi Baradaran, Ali Mohammadi, Behzad Mansoori, Sepideh Chokhachi Baradaran, and Behzad Baradaran, “Growth inhibitory effect of Scrophularia oxysepala extract on mouse mammary carcinoma 4T1 cells in vitro and in vivo systems,” Biomedicine & Pharmacotherapy, 2016. View at Publisher · View at Google Scholar
  • Ali Namvaran, Mehdi Fazeli, Safar Farajnia, Gholamreza Hamidian, and Hassan Rezazadeh, “Apoptosis and Caspase 3 Pathway Role on Anti-Proliferative Effects of Scrophulariaoxy Sepala Methanolic Extract on Caco-2 Cells,” Drug Research, vol. 67, no. 9, pp. 547–552, 2017. View at Publisher · View at Google Scholar
  • Rana Jahanban-Esfahlan, Khaled Seidi, Amir Monfaredan, Vahid Shafie-Irannejad, Mehran Mesgari Abbasi, Ansar Karimian, and Bahman Yousefi, “The herbal medicine Melissa officinalis extract effects on gene expression of p53, Bcl-2, Her2, VEGF-A and hTERT in human lung, breast and prostate cancer cell lines,” Gene, vol. 613, pp. 14–19, 2017. View at Publisher · View at Google Scholar
  • Ardalan Pasdaran, and Azadeh Hamedi, “ The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity ,” Pharmaceutical Biology, vol. 55, no. 1, pp. 2211–2233, 2017. View at Publisher · View at Google Scholar
  • Saeid Heidari-Soreshjani, Majid Asadi-Samani, Qian Yang, and Ali Saeedi-Boroujeni, “Phytotherapy of nephrotoxicity-induced by cancer drugs: An updated review,” Journal of Nephropathology, vol. 6, no. 3, pp. 254–263, 2017. View at Publisher · View at Google Scholar
  • Mehrdad Ghavifekr Fakhr, Kolsoum Rezaie Kahkhaie, Majid Farshdousti Hagh, Elham Safarzadeh, Dariush Shanehbandi, Habib Zarredar, Mina Abdolrahimi Vind, and Behzad Baradaran, “Scrophularia Atropatana extract reverses TP53 gene promoter hypermethylation and decreases survivin antiapoptotic gene expression in breast cancer cells,” Asian Pacific Journal of Cancer Prevention, vol. 19, no. 9, pp. 2599–2605, 2018. View at Publisher · View at Google Scholar
  • Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, and Sameera Ranganath Samarakoon, “In vitro assays and techniques utilized in anticancer drug discovery,” Journal of Applied Toxicology, 2018. View at Publisher · View at Google Scholar