Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells

Figure 1

BBR attenuated hepatic fibrosis induced by BDL in rats. The common bile duct of rat was ligated with 3-0 silk and sectioned between the ligatures. Rats in sham-operated control group had their bile duct exposed without ligation or section. Rats were randomised and received either PBS or BBR (120 mg/kg/day orally) for seven weeks. At the end of the study, rats were sacrificed and the serum and liver were collected. (a) BBR reduced serum ALT and AST in BDL rats. (b) BBR reduced the HyP content in the liver. (c) BBR reduced serum total bile acid (T.Bil) in rats with BDL. (d) Histological analysis revealed that the fibrosis was inhibited by BBR treatment. and versus normal group; and versus the model group.

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