Research Article

Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLC/Q-TOF-MS and Network Pharmacology

Table 5

The herbs of NXT involved in the top 40 pathways.

CategoryPathwayNXTRARPRRSMRASRCXSPFCCSRABRCRMPT

Pathway associated with heart diseases and blood vesselsNFAT and hypertrophy of the heart (transcription in the broken heart)1111110111111
Intrinsic Prothrombin Activation Pathway1011110100010
Extrinsic Prothrombin Activation Pathway1011110100000
Aspirin blocks signaling pathway involved in platelet activation1111110111111
TSP-1 induced apoptosis in microvascular endothelial cell1111110100000
Platelet Amyloid Precursor Protein Pathway1000010100010
Fibrinolysis Pathway1011010100100
Corticosteroids and cardioprotection1101010000010
VEGF, hypoxia, and angiogenesis1111111111111

Pathway associated with metabolismNuclear receptors in lipid metabolism and toxicity1111011101010
Growth Hormone Signaling Pathway1111110111111
Visceral fat deposits and the metabolic syndrome1101110000000

Pathway associated with immunityBCR Signaling Pathway1111110111111
IL-2 Signaling Pathway1111110111111
fMLP induced chemokine gene expression in HMC-1 cells1111110111111
T Cell Receptor Signaling Pathway1111110111111

Pathway associated with cell cycle, proliferation, and apoptosisPhosphoinositides and their downstream targets1001010110000
Estrogen-responsive protein Efp controls cell cycle and breast tumors growth1111110010000
Map kinase inactivation of SMRT corepressor1111110100000
MAP Kinase Signaling Pathway1111110111111
Roles of β-arrestin-dependent recruitment of Src kinases in GPCR signaling1111110111111
Role of ERBB2 in signal transduction and oncology1111110111111
Links between Pyk2 and MAP kinases1111110111111
NF-κB activation by nontypeable Hemophilus influenzae1101110100000
Influence of Ras and Rho proteins on G1 to S transition1111110111111
Cell cycle: G1/S checkpoint1111110010000
Fc epsilon receptor I signaling in mast cells1111110111111
Signaling of hepatocyte growth factor receptor1111110111111
Keratinocyte differentiation1111110111111
RB tumor Suppressor/checkpoint signaling in response to DNA damage1111110010000
IL-3 Signaling Pathway1111110111111
Sprouty regulation of tyrosine kinase signals1111110111111

Other pathwaysBioactive Peptide Induced Signaling Pathway1111110111111
amiPathway1011110100000
Insulin Signaling Pathway1111110111111
p38 MAPK Signaling Pathway1111110111111
The role of FYVE-finger proteins in vesicle transport1000000100000
Mechanism of gene regulation by peroxisome proliferators via PPARα1101010000010
Phosphorylation of MEK1 by cdk5/p35 downregulates the MAP kinase pathway1111110111111
How progesterone initiates oocyte membrane1111111111111

Note. “1” means that the Chinese herbal medicine acts on the pathway while “0” means it does not. The pathways in each category are sorted by the significant differences in P value.