Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats

Figure 6

Liver sections from the experimental animals in (a) Group 1 (saline control) showing a normal liver with a hepatic lobule and a uniform pattern of polyhedral hepatocytes radiating from the central vein (CV) towards the periphery, (b) Group 2 (EECM control) showing a normal appearance of hepatocytes surrounding the CV, and (c) Group 3 (APAP control) demonstrating a disrupted arrangement of hepatocytes around the CV. There was also marked hepatocyte necrosis at the periphery of the CV (red arrow), inflammatory cell infiltration (green arrow), edema at different locations (black arrow), and severe congestion of the CV (d). (e–h) Groups 4, 5, 6 (T 250, T 500, and T 1000 groups, resp.), and 7 (silymarin control) showing a remarkable degree of preservation of the cellular arrangement with only mild inflammation [magnification: 40x; scale bar: 20 μm].

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