Research Article
Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms
Table 2
In vitro effects of isolated compounds against S. mansoni adult worms.
| Groups | Incubation period (h) | Dead worms | Decrease of motor activity | Worms with tegumental alteration | Slight | Significant | | Slight |
| | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
| 0.5% DMSO | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
| | 24 | 100 | 0 | 100 | 0 | 100 | 48 | 100 | 0 | 100 | 0 | 100 | 72 | 100 | 0 | 100 | 0 | 100 |
| Artemetin | | | | | | | 100 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
| Hydroxypelenolide | | | | | | | 100 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72
| 0 | 0 | 0 | 0 | 0 |
| Santin | | | | | | | 100 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
| Apigenin | | | | | | | 100 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
| Parthenolide | | | | | | | 100 µM | 24 | 100 | 0 | 100 | 0 | 100 | 48 | 100 | 0 | 100 | 0 | 100 | 72 | 100 | 0 | 100 | 0 | 100 |
| 50 µM | 24 | 100 | 0 | 100 | 0 | 100 | 48 | 100 | 0 | 100 | 0 | 100 | 72 | 100 | 0 | 100 | 0 | 100 |
| 25 µM | 24 | 100 | 0 | 100 | 0 | 100 | 48 | 100 | 0 | 100 | 0 | 100 | 72 | 100 | 0 | 100 | 0 | 100 |
| 12.5 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 100 | 0 | 100 | 0 | 100 | 72 | 100 | 0 | 100 | 0 | 100 |
| 6.25 µM | 24 | 0 | 0 | 0 | 0 | 0 | 48 | 0 | 0 | 0 | 0 | 0 | 72 | 0 | 0 | 0 | 0 | 0 |
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relative to 20 worms investigated. 1640. at concentration of 5 µM.
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