Research Article

Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

Table 2

In vitro effects of isolated compounds against S. mansoni adult worms.

GroupsIncubation period (h)Dead worms Decrease of motor activity Worms with tegumental alteration
SlightSignificantSlight

2400000
4800000
7200000

0.5% DMSO2400000
4800000
7200000

2410001000100
4810001000100
7210001000100

Artemetin
 100 µM2400000
4800000
7200000

Hydroxypelenolide
 100 µM2400000
4800000
72
00000

Santin
 100 µM2400000
4800000
7200000

Apigenin
 100 µM2400000
4800000
7200000

Parthenolide
 100 µM2410001000100
4810001000100
7210001000100

 50 µM2410001000100
4810001000100
7210001000100

 25 µM2410001000100
4810001000100
7210001000100

 12.5 µM2400000
4810001000100
7210001000100

 6.25 µM2400000
4800000
7200000

relative to 20 worms investigated.
1640.
at concentration of 5 µM.