Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum
Table 2
Cytotoxicity and antioxidant effect of C. leprosum ethanolic extract in S. cerevisiae.
Treatment
Yeast strains
WT
sod1Δ
sod2Δ
sod1Δsod2Δ
NC
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
100.0 ± 0.0
C. leprosum 10 μg/mL
99.33 ± 2.52
89.60 ± 0.95
100.97 ± 3.65
96.00 ± 3.61
C. leprosum 50 μg/mL
99.67 ± 4.73
80.93 ± 3.66
98.57 ± 0.67
94.27 ± 3.95
C. leprosum 100 μg/mL
94.63 ± 4.46
76.43 ± 10.64
94.53 ± 4.17
90.67 ± 0.71
C. leprosum 500 μg/mL
87.23 ± 2.25
67.50 ± 2.12
96.83 ± 3.33
89.63 ± 1.05
PC: H2O2 5 mM
63.03 ± 4.12
16.27 ± 4.88
19.10 ± 4.03
19.33 ± 2.10
C. leprosum 10 μg/mL + H2O2
68.53 ± 1.40
28.3 ± 6.65
31.45 ± 2.19
25.70 ± 2.97
C. leprosum 50 μg/mL + H2O2
68.33 ± 7.16
43.85 ± 2.90
38.35 ± 2.19
41.25 ± 1.91
C. leprosum 100 μg/mL + H2O2
70.80 ± 2.21
41.65 ± 2.76
41.50 ± 3.96
46.70 ± 4.10
C. leprosum 500 μg/mL + H2O2
71.40 ± 5.94
34.90 ± 5.66
38.0 ± 7.49
35.30 ± 6.51
NC: negative control (solvent: DMSO). Positive control (H2O2). Data significant in relation to oxidant-treated samples at and /one-way ANOVA, Tukey’s multiple comparison test.
